SSC4D and HSD3B7

Data Source:
BioGRID (two hybrid)

		SSC4D	HSD3B7
Description		scavenger receptor cysteine rich family member with 4 domains	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane
	Molecular Function	Scavenger Receptor Activity	3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity
	Biological Process	Endocytosis	Bile Acid Biosynthetic Process B Cell Chemotaxis
Pathways			Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs
Diseases			Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC) Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS
Interacting Genes		32 interacting genes: ATXN7L2 CATSPER1 CNNM3 COL8A1 CREB5 CYSRT1 ENKD1 GNE HAPLN2 HOXA1 HSD3B7 KRTAP10-8 KRTAP12-4 KRTAP13-2 KRTAP26-1 KRTAP3-3 MGAT5B NFKBID PCSK5 PLEKHN1 PLSCR4 PRKAB2 PTPMT1 RECK RHOU STK16 TEKT5 TFAP2D TLE5 TRIP13 TROAP VASN	58 interacting genes: ADAMTSL4 AGR2 ANAPC11 APPBP2 ARID5A ASB12 BTN2A2 C22orf39 COMT CREB5 CYSRT1 DAPP1 EFEMP1 EFEMP2 EGFL7 ELOVL4 EMG1 FBLN2 GLRX3 HOXA1 HSD17B13 ICAM1 KPNA4 KPRP KRT31 KRT40 KRT86 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-2 KRTAP4-2 KRTAP5-9 LCE4A LINGO1 MEI4 MEOX2 MGAT5B NOTCH2NLA NR4A3 OTX2 PYGL RBP3 REEP4 RGS17 RUSF1 SPRY2 SSC4D TMEM31 TMX2 TRIM42 YPEL3 ZBTB42 ZNF655
Entrez ID		136853	80270
HPRD ID		06364	09680
Ensembl ID		ENSG00000146700	ENSG00000099377
Uniprot IDs		Q8WTU2	Q9H2F3
PDB IDs
Enriched GO Terms of Interacting Partners?
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