TRIM71 and MIR1-1

Data Source:
BioGRID (unspecified method)

		TRIM71	MIR1-1
Description		tripartite motif containing 71	microRNA 1-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body	Extracellular Space
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Translation Repressor Activity MiRNA Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Complex Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Neural Tube Closure Fibroblast Growth Factor Receptor Signaling Pathway MiRNA Metabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translation Neural Tube Development Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Regulation Of Gene Silencing By MiRNA 3'-UTR-mediated MRNA Destabilization Stem Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Gene Silencing By MiRNA	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Fate Commitment Positive Regulation Of Heart Rate Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Differentiation Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Positive Regulation Of Cardiac Muscle Contraction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Canonical Wnt Signaling Pathway Reversible Differentiation Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Negative Regulation Of Cardiac Conduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Mesoderm Formation Negative Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pulmonary function ( 21946350) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Prostate cancer ( 23535732) Subjective response to lithium treatment in bipolar disorder ( 26503763)
Interacting Genes		11 interacting genes: LIN28B MIR1-1 MIR1-2 MIR100 MIR155 MIR15A MIR18B MIR25 MIR29A MIR29B1 MIRLET7F2	89 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KIN KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A
Entrez ID		131405	406904
HPRD ID		19029
Ensembl ID		ENSG00000206557	ENSG00000199017
Uniprot IDs		Q2Q1W2
PDB IDs
Enriched GO Terms of Interacting Partners?
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