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H3C14 and PKN1
Data Source:
BioGRID
(enzymatic study)
H3C14
PKN1
Description
H3 clustered histone 14
protein kinase N1
Image
GO Annotations
Cellular Component
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Midbody
Cleavage Furrow
Protein-containing Complex
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Nuclear Receptor Coactivator Activity
Small GTPase Binding
Histone Kinase Activity (H3-T11 Specific)
Histone Binding
Histone Deacetylase Binding
Androgen Receptor Binding
Biological Process
RDNA Heterochromatin Assembly
Chromatin Organization
Nucleosome Assembly
Blood Coagulation
Interleukin-7-mediated Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Silencing By MiRNA
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Signal Transduction
Activation Of JUN Kinase Activity
Epithelial Cell Migration
Peptidyl-serine Phosphorylation
Negative Regulation Of B Cell Proliferation
Histone H3-T11 Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Spleen Development
Regulation Of Cell Motility
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
Chromatin modifying enzymes
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Fostamatinib
Diseases
GWAS
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Interacting Genes
60 interacting genes:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFL2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
NAP1L4
NASP
NCOA6
NRDC
NSD2
PHF21A
PIM1
PKN1
PRMT6
PTMA
PWWP3A
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC103
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TRIM27
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
Entrez ID
126961
5585
HPRD ID
11822
03019
Ensembl ID
ENSG00000203811
ENSG00000123143
Uniprot IDs
Q71DI3
Q16512
PDB IDs
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
4MZF
4MZG
4MZH
4OUC
5B0Y
5B0Z
5B40
5BO0
5CIU
5VAC
6ACE
6FML
6T79
6T7A
6T7B
6T7C
6T7D
6X59
6X5A
6XJD
6Y5D
6Y5E
7BQZ
7BU9
7JO9
7JOA
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
Enriched GO Terms of Interacting Partners
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