CYP4F22 and REEP2

Data Source:
BioGRID (two hybrid)

		CYP4F22	REEP2
Description		cytochrome P450 family 4 subfamily F member 22	receptor accessory protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Integral Component Of Plasma Membrane Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding	Protein Binding Microtubule Binding Taste Receptor Binding
	Biological Process	Icosanoid Metabolic Process Ceramide Biosynthetic Process	Regulation Of Intracellular Transport Protein Transport Into Membrane Raft Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Endoplasmic Reticulum Tubular Network Organization
Pathways		Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)	Olfactory Signaling Pathway
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061)
Interacting Genes		4 interacting genes: AQP6 MSMO1 REEP2 TLCD4	24 interacting genes: BNIP3 C2CD2L CMTM5 CYP4F2 CYP4F22 ITGAM MS4A1 MUL1 NAT8 ORMDL3 RABAC1 SCD SFT2D2 SLC25A46 TMBIM6 TMEM120B TMEM208 TMEM239 TMEM31 TMEM42 TMEM60 TMX2 TTPA YIF1A
Entrez ID		126410	51308
HPRD ID		08256	16655
Ensembl ID		ENSG00000171954	ENSG00000132563
Uniprot IDs		Q6NT55	A8K3D2 Q9BRK0
PDB IDs
Enriched GO Terms of Interacting Partners?
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