CYP4F22 and TLCD4

Data Source:
BioGRID (two hybrid)

		CYP4F22	TLCD4
Description		cytochrome P450 family 4 subfamily F member 22	TLC domain containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cellular_component Endoplasmic Reticulum Integral Component Of Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding	Molecular_function Protein Binding
	Biological Process	Icosanoid Metabolic Process Ceramide Biosynthetic Process	Biological_process Lipid Homeostasis
Pathways		Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		4 interacting genes: AQP6 MSMO1 REEP2 TLCD4	71 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC22A18 SLC41A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4
Entrez ID		126410	148534
HPRD ID		08256	08110
Ensembl ID		ENSG00000171954	ENSG00000152078
Uniprot IDs		Q6NT55	Q96MV1
PDB IDs
Enriched GO Terms of Interacting Partners?
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