USP43 and H2BC3

Data Source:
BioGRID (enzymatic study)

		USP43	H2BC3
Description		ubiquitin specific peptidase 43	H2B clustered histone 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Cytosol
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity ISG15-specific Protease Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Translesion Synthesis	Nucleosome Assembly Protein Ubiquitination
Pathways		Termination of translesion DNA synthesis	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778)
Interacting Genes		3 interacting genes: H2BC3 HDAC1 YWHAE	25 interacting genes: AKT1 APP CDK1 CDK2 CREBBP DYRK1A EID1 EP300 ERCC6 FANCD2 H2AC4 KAT2B MYB PALB2 PSMD4 RHBDD2 RNF20 RNF8 RPS6KA5 UBR7 UHRF1 USP16 USP36 USP43 USP51
Entrez ID		124739	3018
HPRD ID		18926	07536
Ensembl ID		ENSG00000154914	ENSG00000276410
Uniprot IDs		Q70EL4	P33778
PDB IDs			3X1S 3X1U
Enriched GO Terms of Interacting Partners?
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