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CCR1 and CCL8
Data Source:
HPRD
(in vivo)
CCR1
CCL8
Description
C-C motif chemokine receptor 1
C-C motif chemokine ligand 8
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Extracellular Space
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Chemokine Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Chemokine (C-C Motif) Ligand 7 Binding
Chemokine (C-C Motif) Ligand 5 Binding
Protein Kinase Activity
Protein Binding
Chemokine Activity
Heparin Binding
Phospholipase Activator Activity
CCR Chemokine Receptor Binding
Biological Process
Dendritic Cell Chemotaxis
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Immune Response
Cell Adhesion
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Response To Wounding
Negative Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Calcium-mediated Signaling
Positive Regulation Of Cell Migration
Negative Regulation Of Bone Mineralization
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Calcium Ion Transport
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Monocyte Chemotaxis
Monocyte Chemotaxis
Positive Regulation Of Leukocyte Migration
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Response To Virus
Neutrophil Chemotaxis
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Genome Replication
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Leukocyte Proliferation
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
Pidolic acid
Diseases
GWAS
Arthritis (juvenile idiopathic) (
33106285
)
Behcet's disease (
23291587
)
Celiac disease (
22057235
20190752
30572963
18311140
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
26192919
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Narcolepsy with cataplexy (
25986216
)
Ulcerative colitis (
26192919
28067908
)
Blood protein levels (
30072576
29875488
28240269
)
Crohn's disease (
22412388
)
Interacting Genes
29 interacting genes:
CCL14
CCL15
CCL16
CCL2
CCL23
CCL26
CCL3
CCL3L1
CCL4
CCL5
CCL7
CCL8
CD74
CREB3
FAN1
GNA14
GRAMD1A
JAK1
LETMD1
MBP
PLP2
PRNP
QSOX1
STAT1
STAT3
TMEFF1
TMX1
TPST1
TPST2
20 interacting genes:
ACKR1
ACKR2
ACKR4
CCL11
CCL13
CCL2
CCL26
CCR1
CCR3
CCR5
CXCL10
CXCL11
CXCL17
CXCL2
CXCL6
CXCL8
MMP3
PPBP
VCAN
XCL2
Entrez ID
1230
6355
HPRD ID
03101
03791
Ensembl ID
ENSG00000163823
ENSG00000108700
Uniprot IDs
P32246
Q5U003
P80075
PDB IDs
1Y5D
1ESR
Enriched GO Terms of Interacting Partners
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