CCR1 and FAN1

Data Source:
BioGRID (two hybrid)

		CCR1	FAN1
Description		C-C motif chemokine receptor 1	FANCD2 and FANCI associated nuclease 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Nucleus Nucleoplasm Cytosol Intercellular Bridge
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Magnesium Ion Binding Phosphodiesterase I Activity Protein Binding 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity Flap-structured DNA Binding Ubiquitin-dependent Protein Binding
	Biological Process	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis	Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision Interstrand Cross-link Repair
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Behcet's disease ( 23291587) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)	Huntington's disease (age at onset) ( 29750799) Huntington's disease progression ( 28642124)
Interacting Genes		29 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2	4 interacting genes: CCR1 MLH1 PCNA UBC
Entrez ID		1230	22909
HPRD ID		03101	17205
Ensembl ID		ENSG00000163823	ENSG00000198690
Uniprot IDs		P32246 Q5U003	Q9Y2M0
PDB IDs		1Y5D	4REA 4REB 4REC 4RI8 4RI9 4RIA 4RIB 4RIC 4RID 4RY3
Enriched GO Terms of Interacting Partners?
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