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CCR1 and LETMD1
Data Source:
BioGRID
(two hybrid)
CCR1
LETMD1
Description
C-C motif chemokine receptor 1
LETM1 domain containing 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Nucleoplasm
Nucleolus
Mitochondrion
Mitochondrial Outer Membrane
Integral Component Of Membrane
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Chemokine Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Chemokine (C-C Motif) Ligand 7 Binding
Chemokine (C-C Motif) Ligand 5 Binding
Protein Binding
Ribosome Binding
Biological Process
Dendritic Cell Chemotaxis
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Immune Response
Cell Adhesion
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Response To Wounding
Negative Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Calcium-mediated Signaling
Positive Regulation Of Cell Migration
Negative Regulation Of Bone Mineralization
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Calcium Ion Transport
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Monocyte Chemotaxis
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
Diseases
GWAS
Arthritis (juvenile idiopathic) (
33106285
)
Behcet's disease (
23291587
)
Celiac disease (
22057235
20190752
30572963
18311140
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
26192919
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Narcolepsy with cataplexy (
25986216
)
Ulcerative colitis (
26192919
28067908
)
Interacting Genes
29 interacting genes:
CCL14
CCL15
CCL16
CCL2
CCL23
CCL26
CCL3
CCL3L1
CCL4
CCL5
CCL7
CCL8
CD74
CREB3
FAN1
GNA14
GRAMD1A
JAK1
LETMD1
MBP
PLP2
PRNP
QSOX1
STAT1
STAT3
TMEFF1
TMX1
TPST1
TPST2
10 interacting genes:
APOC1
APOC2
APOC4
APP
CCR1
FBXO7
HCK
RHBDD2
SH2D1A
TMEM167B
Entrez ID
1230
25875
HPRD ID
03101
09978
Ensembl ID
ENSG00000163823
ENSG00000050426
Uniprot IDs
P32246
Q5U003
A0A384P5D7
F8W1Z2
Q6P1Q0
PDB IDs
1Y5D
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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