CCL8 and ACKR1

Data Source:
HPRD (in vivo)

		CCL8	ACKR1
Description		C-C motif chemokine ligand 8	atypical chemokine receptor 1 (Duffy blood group)
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GO Annotations	Cellular Component	Extracellular Space	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome
	Molecular Function	Protein Kinase Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity C-C Chemokine Binding Signaling Receptor Activity
	Biological Process	Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Genome Replication Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Defense Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway
Pathways			Peptide ligand-binding receptors
Drugs		Pidolic acid
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 22412388)	Eotaxin levels ( 27989323) Growth-regulated protein alpha levels ( 27989323) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Monocyte chemoattractant protein-1 levels ( 27989323 31217265) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433)
Interacting Genes		20 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP VCAN XCL2	9 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8 MTNR1B
Entrez ID		6355	2532
HPRD ID		03791	00192
Ensembl ID		ENSG00000108700	ENSG00000213088
Uniprot IDs		P80075	Q16570 Q5Y7A1 Q5Y7A2
PDB IDs		1ESR	4NUU 4NUV
Enriched GO Terms of Interacting Partners?
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