CLPTM1 and CCR4

Data Source:
BioGRID (two hybrid)

		CLPTM1	CCR4
Description		CLPTM1 regulator of GABA type A receptor forward trafficking	C-C motif chemokine receptor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endomembrane System Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body
	Molecular Function	Protein Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Multicellular Organism Development Cell Differentiation Regulation Of T Cell Differentiation In Thymus	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Calcium-mediated Signaling Response To Antibiotic Homeostasis Of Number Of Cells Positive Regulation Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Mogamulizumab FLX475
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein B levels ( 32203549) Basal cell carcinoma ( 31174203) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels ( 32203549) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Asthma ( 31959851) Celiac disease ( 22057235 20190752) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)
Interacting Genes		8 interacting genes: CCR2 CCR4 F2RL1 FZD7 LINC00839 SLC22A1 SLC22A2 UNC93B1	37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1
Entrez ID		1209	1233
HPRD ID		07544	05324
Ensembl ID		ENSG00000104853	ENSG00000183813
Uniprot IDs		A0A0S2Z3H2 O96005	A0N0Q1 P51679
PDB IDs
Enriched GO Terms of Interacting Partners?
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