CCR4 and B3GAT3

Data Source:
BioGRID (two hybrid)

		CCR4	B3GAT3
Description		C-C motif chemokine receptor 4	beta-1,3-glucuronyltransferase 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Protein Binding Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Activity Glucuronosyltransferase Activity Metal Ion Binding Protein Phosphatase Activator Activity
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Calcium-mediated Signaling Response To Antibiotic Homeostasis Of Number Of Cells Positive Regulation Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Phosphoprotein Phosphatase Activity Chondroitin Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	A tetrasaccharide linker sequence is required for GAG synthesis Defective B3GAT3 causes JDSSDHD
Drugs		Mogamulizumab FLX475	UDP-alpha-D-glucuronic acid Uridine-5'-Diphosphate
Diseases
GWAS		Asthma ( 31959851) Celiac disease ( 22057235 20190752) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)	Blood protein levels ( 29875488) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1	5 interacting genes: CCR2 CCR4 GPR35 HNRNPD SEC22B
Entrez ID		1233	26229
HPRD ID		05324	07564
Ensembl ID		ENSG00000183813	ENSG00000149541
Uniprot IDs		A0N0Q1 P51679	G3V150 O94766 Q5U676
PDB IDs			1FGG 1KWS 3CU0
Enriched GO Terms of Interacting Partners?
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