CCR4 and SLC12A5

Data Source:
BioGRID (two hybrid)

		CCR4	SLC12A5
Description		C-C motif chemokine receptor 4	solute carrier family 12 member 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection Neuronal Cell Body Synapse Cell Periphery
	Molecular Function	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Chloride Transmembrane Transporter Activity Potassium:chloride Symporter Activity
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Calcium-mediated Signaling Response To Antibiotic Homeostasis Of Number Of Cells Positive Regulation Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway	Ion Transport Cellular Ion Homeostasis Cell Volume Homeostasis Hypotonic Response Chemical Synaptic Transmission Learning Cellular Chloride Ion Homeostasis Multicellular Organism Growth Thermosensory Behavior Response To Drug Chloride Ion Homeostasis Potassium Ion Homeostasis Dendritic Spine Development Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Cation-coupled Chloride cotransporters
Drugs		Mogamulizumab FLX475	Potassium chloride Bumetanide
Diseases
GWAS		Asthma ( 31959851) Celiac disease ( 22057235 20190752) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)	Chronotype ( 30696823) Crohn's disease ( 28067908) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 28067908) Reticulocyte count ( 32888494) Systemic sclerosis ( 29293537) Triglyceride levels ( 32154731)
Interacting Genes		37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1	2 interacting genes: CCR4 F2RL1
Entrez ID		1233	57468
HPRD ID		05324	09469
Ensembl ID		ENSG00000183813	ENSG00000124140
Uniprot IDs		A0N0Q1 P51679	Q9H2X9
PDB IDs			6M23
Enriched GO Terms of Interacting Partners?
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