STUB1 and PLK1

Data Source:
BioGRID (enzymatic study)

		STUB1	PLK1
Description		STIP1 homology and U-box containing protein 1	polo like kinase 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Chaperone Complex	Kinetochore Chromatin Synaptonemal Complex Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Centriolar Satellite Spindle Midzone Mitotic Spindle Pole
	Molecular Function	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Anaphase-promoting Complex Binding Kinase Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Heat ERBB2 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Cytokinesis Microtubule Bundle Formation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Sister Chromatid Cohesion Mitotic Nuclear Envelope Disassembly Mitotic Spindle Assembly Checkpoint Centrosome Cycle Regulation Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Peptidyl-threonine Phosphorylation Female Meiosis Chromosome Segregation Protein Ubiquitination Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Homologous Chromosome Segregation Establishment Of Protein Localization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Proteolysis Nuclear Envelope Disassembly Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Synaptonemal Complex Disassembly Protein Localization To Chromatin Signal Transduction Involved In G2 DNA Damage Checkpoint Protein Localization To Nuclear Envelope Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Spindle Assembly Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Protein Localization To Cell Cortex
Pathways		Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase Mitotic Metaphase/Anaphase Transition Mitotic Telophase/Cytokinesis Cyclin A/B1/B2 associated events during G2/M transition The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs			3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea Wortmannin Fostamatinib
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		126 interacting genes: ABL1 ACD AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BCR BMPR1B CASP6 CCL28 CDK4 CDKN1A CFTR CIP2A CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 E2F8 EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A1 GUCY1A2 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 INSR JOSD1 JOSD2 KHDRBS1 LRRK1 LRRK2 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 PA2G4 PFN1 PLK1 POLB POT1 POU5F1 PPARG PPP3CA PRKACA PRKCZ PRKN PRMT1 PRMT5 PSMA3 PSMD4 PTEN RAF1 RGS17 RHBDF2 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TPD52 TRAF6 TXN2 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W VCP XIAP	120 interacting genes: - ACTL6B APP ASPM BAG6 BCL2L1 BIRC6 BRCA2 BUB1 BUB1B C6orf136 CCDC115 CCNB1 CDC14A CDC25C CENPQ CEP55 CHEK2 CSN1S1 CSN2 CTNNB1 DNAJB9 DNHD1 ECT2 EIF6 FBXL5 FBXW7 FZR1 GET4 GLB1 GORASP1 IKBKB INTS11 ITSN1 KIF23 KIF2C KLF4 KLHL22 KRBA1 LMO4 LRP5L LRRK1 LRRK2 MAD2L1BP MAGED1 MCM2 MCM3 MCM7 MDM2 MPP2 MYC MYT1 NEDD4 NHSL2 NINL NPM1 NUDC PARP10 PHC2 PIN1 PITPNM1 PKMYT1 PLK3 PPID PRC1 PRKN PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PTEN PTPRD RABAC1 RACGAP1 RAD51 RAP1GAP RECQL5 RELA REST RGCC RICTOR RNF126 RNF2 RXRA SIMC1 SNCA SNCB SPOUT1 SREBF1 STAG2 STK3 STUB1 SUGT1 TANK TNFSF11 TOP2A TP53 TP53BP2 TP73 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 USP16 USP7 VRK3 WEE1 ZNF71
Entrez ID		10273	5347
HPRD ID		06232	03652
Ensembl ID		ENSG00000103266	ENSG00000166851
Uniprot IDs		Q9UNE7	P53350
PDB IDs		4KBQ 6EFK 6NSV	1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53 4LKL 4LKM 4O56 4O6W 4O9W 4RCP 4WHH 4WHK 4WHL 4X9R 4X9V 4X9W 5J19 5NEI 5NFU 5NJE 5NMM 5NN1 5NN2 5TA6 5TA8 6AX4 6GY2
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?