MOCS3 and XRN2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MOCS3	XRN2
Description		molybdenum cofactor synthesis 3	5'-3' exoribonuclease 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Membrane Aggresome
	Molecular Function	Thiosulfate Sulfurtransferase Activity Protein Binding ATP Binding Nucleotidyltransferase Activity Sulfurtransferase Activity URM1 Activating Enzyme Activity Metal Ion Binding Molybdopterin-synthase Sulfurtransferase Activity Molybdopterin-synthase Adenylyltransferase Activity	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding
	Biological Process	TRNA Wobble Uridine Modification TRNA Wobble Position Uridine Thiolation Mo-molybdopterin Cofactor Biosynthetic Process Protein Phosphopantetheinylation Molybdopterin Cofactor Biosynthetic Process Protein Urmylation TRNA Thio-modification	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Molybdenum cofactor biosynthesis	Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: EXOSC6 MOCS2 XRN2	28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2
Entrez ID		27304	22803
HPRD ID		10092	10309
Ensembl ID		ENSG00000124217	ENSG00000088930
Uniprot IDs		O95396	B4DZC3 Q9H0D6
PDB IDs		3I2V
Enriched GO Terms of Interacting Partners?
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