ZMYND19 and PRMT5

Data Source:
BioGRID (two hybrid)

		ZMYND19	PRMT5
Description		zinc finger MYND-type containing 19	protein arginine methyltransferase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Synapse	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Histone Methyltransferase Complex
	Molecular Function	Protein Binding Metal Ion Binding	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity E-box Binding
	Biological Process		Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression Histone Arginine Methylation Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation Regulation Of DNA Methylation Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Pathways			snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS		Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Systolic blood pressure ( 30578418)	Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		52 interacting genes: ANKRD55 C19orf54 CBWD1 CBWD3 CBWD5 CCNI CEACAM6 CPSF6 DTX3 ENOX1 FIP1L1 FNDC3B GAPDHS GGN GMEB2 GORASP2 GRB10 GSE1 GTF2F2 HACL1 HOMEZ INCA1 KCTD13 KCTD21 LZTS1 LZTS2 MCHR1 MLLT6 NAB2 PNMA5 PPP1R37 PRKAB2 PRKAR1B PRMT5 PSMA1 PTGES3L-AARSD1 RFX6 SAXO1 SCN5A SELENOV SS18L1 TBRG1 TNFAIP1 TNNT1 TOLLIP TOX4 TRIM27 TRIM45 TUBB WDR77 ZBTB2 ZXDC	91 interacting genes: ARGLU1 C1orf109 CACNB2 CALU CAPN1 CDC37 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A CTDP1 DIO3 DNMT3A DUSP14 EIF4A3 ELOA EPHB6 EZH2 FAM76B GAS8 GLI1 GRHL3 GTPBP2 H2AC20 H2AC4 H3-4 H3-5 H3C1 H4-16 H4C1 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 KANK2 LDHAL6B LENG8 LNX1 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NCL NELFCD NTAQ1 NUDCD2 OLA1 PDGFRA PHYHIP POLR2A PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 STUB1 SUPT5H TRIB3 TRIM54 TYK2 UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZMYND19 ZNF2 ZNF224 ZNF436 ZUP1
Entrez ID		116225	10419
HPRD ID		15743	04955
Ensembl ID		ENSG00000165724	ENSG00000100462
Uniprot IDs		Q96E35	B4DV00 O14744
PDB IDs			4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UXX 6UXY 6V0N 6V0O
Enriched GO Terms of Interacting Partners?
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