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PRMT5 and H2AC4
Data Source:
BioGRID
(enzymatic study)
PRMT5
H2AC4
Description
protein arginine methyltransferase 5
H2A clustered histone 4
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Methylosome
Histone Methyltransferase Complex
Nucleosome
Nucleus
Extracellular Exosome
Molecular Function
P53 Binding
Transcription Corepressor Activity
Protein Binding
Methyltransferase Activity
Methyl-CpG Binding
Histone-arginine N-methyltransferase Activity
Protein-arginine N-methyltransferase Activity
Protein-arginine Omega-N Symmetric Methyltransferase Activity
Identical Protein Binding
Ribonucleoprotein Complex Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Protein Heterodimerization Activity
E-box Binding
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Spliceosomal SnRNP Assembly
DNA-templated Transcription, Termination
Regulation Of Transcription, DNA-templated
Regulation Of Mitotic Nuclear Division
Peptidyl-arginine Methylation
Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine
Circadian Regulation Of Gene Expression
Histone Arginine Methylation
Peptidyl-arginine N-methylation
Endothelial Cell Activation
Histone H4-R3 Methylation
Regulation Of DNA Methylation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of ERK1 And ERK2 Cascade
Golgi Ribbon Formation
Liver Regeneration
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Chromatin Silencing
Negative Regulation Of Cell Population Proliferation
Pathways
snRNP Assembly
RMTs methylate histone arginines
Regulation of TP53 Activity through Methylation
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Cortical amyloid beta load (
29860282
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Interacting Genes
91 interacting genes:
ARGLU1
C1orf109
CACNB2
CALU
CAPN1
CDC37
CDK19
CDK8
CDYL2
CLK1
CLK3
CLNS1A
CTDP1
DIO3
DNMT3A
DUSP14
EIF4A3
ELOA
EPHB6
EZH2
FAM76B
GAS8
GLI1
GRHL3
GTPBP2
H2AC20
H2AC4
H3-4
H3-5
H3C1
H4-16
H4C1
HOXC4
ILF3
ING5
JAK1
JAK2
JAK3
KANK2
LDHAL6B
LENG8
LNX1
LUC7L
MAGEB2
MBP
MCRS1
MEF2D
MYOD1
MYOG
NCL
NELFCD
NTAQ1
NUDCD2
OLA1
PDGFRA
PHYHIP
POLR2A
PRPF38A
RBM23
RSRP1
SF3A3
SIN3A
SLU7
SMARCA2
SMARCB1
SMARCC1
SMARCE1
SNRNP70
SNRPB
SNRPD1
SNRPD3
SPAG8
SREBF1
SSTR1
STUB1
SUPT5H
TRIB3
TRIM54
TYK2
UBE3A
WDR5
WDR77
YWHAG
YWHAQ
YWHAZ
ZDHHC17
ZMYND19
ZNF2
ZNF224
ZNF436
ZUP1
25 interacting genes:
BAP1
BMI1
BRCA1
CDK1
CDK2
EIF2AK2
EP300
FANCD2
H2BC15
H2BC3
KAT2B
KAT5
MAP4K1
MYB
PRMT5
PSMD4
PTEN
RNF168
RNF2
RPL6
TRIM37
UBE2D3
UHRF1
USP16
USP51
Entrez ID
10419
8335
HPRD ID
04955
09105
Ensembl ID
ENSG00000100462
ENSG00000278463
Uniprot IDs
B4DV00
O14744
P04908
Q08AJ9
PDB IDs
4GQB
4X60
4X61
4X63
5C9Z
5EMJ
5EMK
5EML
5EMM
5FA5
6CKC
6K1S
6RLL
6RLQ
6UXX
6UXY
6V0N
6V0O
2CV5
2RVQ
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3W96
3W97
3W98
3W99
3WKJ
3WTP
3X1S
3X1V
4YM5
4YM6
4Z5T
5AV5
5AV6
5AV8
5AV9
5AVB
5AVC
5AY8
5B0Y
5B0Z
5B24
5B2I
5B2J
5B31
5B32
5B40
5CPI
5CPJ
5CPK
5GSE
5GTC
5GXQ
5JRG
5X7X
5XF3
5XF4
5XF5
5Y0C
5Y0D
5Z23
5ZBX
6A5L
6A5O
6A5P
6A5R
6A5T
6A5U
6ACL
6AEE
6BUZ
6E0C
6E0P
6HKT
6HTS
6INQ
6IPU
6IQ4
6IR9
6J4W
6J4X
6J4Y
6J4Z
6J50
6J51
6JR0
6JR1
6JXD
6KE9
6KXV
6L49
6L4A
6L9H
6LA8
6LA9
6LE9
6M3V
6M44
6O1D
6R8Y
6R8Z
6R90
6R91
6R92
6R93
6R94
6T79
6T7A
6T7B
6T7C
6T7D
6T90
6T93
6V92
6YOV
7C0M
7CCQ
7CCR
Enriched GO Terms of Interacting Partners
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