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PRMT5 and GRHL3
Data Source:
BioGRID
(two hybrid)
PRMT5
GRHL3
Description
protein arginine methyltransferase 5
grainyhead like transcription factor 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Methylosome
Histone Methyltransferase Complex
Chromatin
Nucleus
Nucleoplasm
Molecular Function
P53 Binding
Transcription Corepressor Activity
Protein Binding
Methyltransferase Activity
Methyl-CpG Binding
Histone-arginine N-methyltransferase Activity
Protein-arginine N-methyltransferase Activity
Protein-arginine Omega-N Symmetric Methyltransferase Activity
Identical Protein Binding
Ribonucleoprotein Complex Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Protein Heterodimerization Activity
E-box Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Chromatin DNA Binding
Sequence-specific DNA Binding
Biological Process
Spliceosomal SnRNP Assembly
DNA-templated Transcription, Termination
Regulation Of Transcription, DNA-templated
Regulation Of Mitotic Nuclear Division
Peptidyl-arginine Methylation
Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine
Circadian Regulation Of Gene Expression
Histone Arginine Methylation
Peptidyl-arginine N-methylation
Endothelial Cell Activation
Histone H4-R3 Methylation
Regulation Of DNA Methylation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of ERK1 And ERK2 Cascade
Golgi Ribbon Formation
Liver Regeneration
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Establishment Of Planar Polarity
Neural Tube Closure
Regulation Of Transcription By RNA Polymerase II
Pattern Specification Process
Ectoderm Development
Central Nervous System Development
Epidermis Development
Regulation Of Actin Cytoskeleton Organization
Wound Healing
Positive Regulation Of GTPase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Eyelid Development In Camera-type Eye
Establishment Of Skin Barrier
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways
snRNP Assembly
RMTs methylate histone arginines
Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS
Cortical amyloid beta load (
29860282
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Cleft palate (
28054174
27018472
)
Fasting blood insulin (BMI interaction) (
22581228
)
Male-pattern baldness (
28196072
)
Response to interferon beta in multiple sclerosis (
26644207
)
Interacting Genes
91 interacting genes:
ARGLU1
C1orf109
CACNB2
CALU
CAPN1
CDC37
CDK19
CDK8
CDYL2
CLK1
CLK3
CLNS1A
CTDP1
DIO3
DNMT3A
DUSP14
EIF4A3
ELOA
EPHB6
EZH2
FAM76B
GAS8
GLI1
GRHL3
GTPBP2
H2AC20
H2AC4
H3-4
H3-5
H3C1
H4-16
H4C1
HOXC4
ILF3
ING5
JAK1
JAK2
JAK3
KANK2
LDHAL6B
LENG8
LNX1
LUC7L
MAGEB2
MBP
MCRS1
MEF2D
MYOD1
MYOG
NCL
NELFCD
NTAQ1
NUDCD2
OLA1
PDGFRA
PHYHIP
POLR2A
PRPF38A
RBM23
RSRP1
SF3A3
SIN3A
SLU7
SMARCA2
SMARCB1
SMARCC1
SMARCE1
SNRNP70
SNRPB
SNRPD1
SNRPD3
SPAG8
SREBF1
SSTR1
STUB1
SUPT5H
TRIB3
TRIM54
TYK2
UBE3A
WDR5
WDR77
YWHAG
YWHAQ
YWHAZ
ZDHHC17
ZMYND19
ZNF2
ZNF224
ZNF436
ZUP1
8 interacting genes:
EAF1
ENKD1
GRHL1
GRHL2
PRMT1
PRMT5
PRMT6
RIPPLY1
Entrez ID
10419
57822
HPRD ID
04955
12210
Ensembl ID
ENSG00000100462
ENSG00000158055
Uniprot IDs
B4DV00
O14744
Q8TE85
PDB IDs
4GQB
4X60
4X61
4X63
5C9Z
5EMJ
5EMK
5EML
5EMM
5FA5
6CKC
6K1S
6RLL
6RLQ
6UXX
6UXY
6V0N
6V0O
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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