Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PRMT5 and CDC37
Data Source:
BioGRID
(two hybrid)
PRMT5
CDC37
Description
protein arginine methyltransferase 5
cell division cycle 37, HSP90 cochaperone
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Methylosome
Histone Methyltransferase Complex
Cytoplasm
Cytosol
Extracellular Exosome
Chaperone Complex
HSP90-CDC37 Chaperone Complex
Molecular Function
P53 Binding
Transcription Corepressor Activity
Protein Binding
Methyltransferase Activity
Methyl-CpG Binding
Histone-arginine N-methyltransferase Activity
Protein-arginine N-methyltransferase Activity
Protein-arginine Omega-N Symmetric Methyltransferase Activity
Identical Protein Binding
Ribonucleoprotein Complex Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Protein Heterodimerization Activity
E-box Binding
Protein Binding
Protein Kinase Regulator Activity
Kinase Binding
Protein Kinase Binding
Heat Shock Protein Binding
Unfolded Protein Binding
Chaperone Binding
Hsp90 Protein Binding
Scaffold Protein Binding
Biological Process
Spliceosomal SnRNP Assembly
DNA-templated Transcription, Termination
Regulation Of Transcription, DNA-templated
Regulation Of Mitotic Nuclear Division
Peptidyl-arginine Methylation
Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine
Circadian Regulation Of Gene Expression
Histone Arginine Methylation
Peptidyl-arginine N-methylation
Endothelial Cell Activation
Histone H4-R3 Methylation
Regulation Of DNA Methylation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of ERK1 And ERK2 Cascade
Golgi Ribbon Formation
Liver Regeneration
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Folding
Protein Targeting
Posttranscriptional Regulation Of Gene Expression
ERBB2 Signaling Pathway
Protein Stabilization
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Pathways
snRNP Assembly
RMTs methylate histone arginines
Regulation of TP53 Activity through Methylation
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Constitutive Signaling by EGFRvIII
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
RHOBTB2 GTPase cycle
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS
Cortical amyloid beta load (
29860282
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Multiple sclerosis (
21833088
)
White blood cell count (
32888494
)
Interacting Genes
91 interacting genes:
ARGLU1
C1orf109
CACNB2
CALU
CAPN1
CDC37
CDK19
CDK8
CDYL2
CLK1
CLK3
CLNS1A
CTDP1
DIO3
DNMT3A
DUSP14
EIF4A3
ELOA
EPHB6
EZH2
FAM76B
GAS8
GLI1
GRHL3
GTPBP2
H2AC20
H2AC4
H3-4
H3-5
H3C1
H4-16
H4C1
HOXC4
ILF3
ING5
JAK1
JAK2
JAK3
KANK2
LDHAL6B
LENG8
LNX1
LUC7L
MAGEB2
MBP
MCRS1
MEF2D
MYOD1
MYOG
NCL
NELFCD
NTAQ1
NUDCD2
OLA1
PDGFRA
PHYHIP
POLR2A
PRPF38A
RBM23
RSRP1
SF3A3
SIN3A
SLU7
SMARCA2
SMARCB1
SMARCC1
SMARCE1
SNRNP70
SNRPB
SNRPD1
SNRPD3
SPAG8
SREBF1
SSTR1
STUB1
SUPT5H
TRIB3
TRIM54
TYK2
UBE3A
WDR5
WDR77
YWHAG
YWHAQ
YWHAZ
ZDHHC17
ZMYND19
ZNF2
ZNF224
ZNF436
ZUP1
178 interacting genes:
A2M
ACTB
ACTG1
AKT1
AMOTL2
APOE
APP
AR
BEND7
BHLHB9
BLZF1
BTBD10
BTBD3
C19orf44
CAMK2A
CAMK2B
CAMK2G
CARD10
CARD9
CAVIN1
CBY2
CC2D1A
CCDC138
CCDC152
CCDC91
CCHCR1
CDC37L1
CDK2
CDK3
CDK4
CDK5
CDK6
CDK7
CEP55
CEP70
CGGBP1
CHGA
CHUK
CKS1B
CKS2
CRYM
CSNK2A1
CSNK2A2
CT45A1
CTAG1A
CTAG1B
CUTC
CYP2C9
DCTN1
DEAF1
DISC1
ECSIT
EIF2AK1
EIF2S1
ELAVL3
ENOX2
EXOSC1
FAM118A
FAM9B
FATE1
FBXL12
FBXW4
GAS7
GAS8
GCDH
GCH1
GFAP
GMCL1
GOLGA2
GOLGA6L9
GRAMD2B
GRIPAP1
HIVEP1
HOMER3
HSF2BP
HSP90AA1
IFIT5
IKBKB
IKBKE
IKBKG
IKZF3
IMMT
JRK
KATNBL1
KCTD13
KCTD9
KIFC3
KLHL2
KRT75
KRT76
LMNB2
LONP1
LOXL4
LUC7L2
LZTS1
MAD1L1
MAP3K14
MAP3K3
MDFI
MID1
MIPOL1
MRPL9
MTOR
MZT2B
NCOA5
NECAB1
NECAB2
NOS3
NR2C2
NRIP3
NT5C1A
OGA
PAICS
PDE9A
PIBF1
PNMA2
POU6F2
PPHLN1
PPP5C
PRAM1
PRDX2
PRKAR1B
PRMT1
PRMT5
PRPH
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMC6
PSME1
PTGES3
RABGEF1
RAD23A
RAF1
REEP6
RNF32
ROPN1
RPS15A
SAFB
SEPTIN3
SNX5
SPTBN4
SQSTM1
SRC
SRRM4
SSNA1
STAMBPL1
STIP1
STK11
STK32A
STX1A
SYCE2
SYCP3
TBK1
TCF4
THAP1
THAP7
TNFAIP1
TNIP1
TRAF2
TRAF3
TRAF5
TRIM54
UBE2I
USHBP1
WAC
ZBED1
ZBTB26
ZBTB8A
ZNF205
ZNF235
ZNF266
ZNF276
ZNF655
ZNF667
ZNF837
Entrez ID
10419
11140
HPRD ID
04955
05456
Ensembl ID
ENSG00000100462
ENSG00000105401
Uniprot IDs
B4DV00
O14744
A0A024R7B7
Q16543
PDB IDs
4GQB
4X60
4X61
4X63
5C9Z
5EMJ
5EMK
5EML
5EMM
5FA5
6CKC
6K1S
6RLL
6RLQ
6UXX
6UXY
6V0N
6V0O
1US7
2K5B
2N5X
2NCA
2W0G
5FWK
5FWL
5FWM
5FWP
5HPE
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?