ZMYND19 and GRB10

Data Source:
BioGRID (two hybrid)

		ZMYND19	GRB10
Description		zinc finger MYND-type containing 19	growth factor receptor bound protein 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Synapse	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding Metal Ion Binding	Insulin Receptor Binding Protein Binding
	Biological Process		Axon Guidance Insulin Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways			Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling FLT3 Signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Systolic blood pressure ( 30578418)	Acute lymphoblastic leukemia (childhood) ( 23512250) Area under the curve of insulin levels ( 24699409) Birth weight ( 31043758) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Corpus callosum mid-anterior volume ( 31530798) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Diastolic blood pressure ( 30224653) Eosinophil counts ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Femoral neck bone mineral density ( 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Incremental insulin ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia (treatment resistant) ( 25223841) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 21779181) Total body bone mineral density ( 29304378)
Interacting Genes		52 interacting genes: ANKRD55 C19orf54 CBWD1 CBWD3 CBWD5 CCNI CEACAM6 CPSF6 DTX3 ENOX1 FIP1L1 FNDC3B GAPDHS GGN GMEB2 GORASP2 GRB10 GSE1 GTF2F2 HACL1 HOMEZ INCA1 KCTD13 KCTD21 LZTS1 LZTS2 MCHR1 MLLT6 NAB2 PNMA5 PPP1R37 PRKAB2 PRKAR1B PRMT5 PSMA1 PTGES3L-AARSD1 RFX6 SAXO1 SCN5A SELENOV SS18L1 TBRG1 TNFAIP1 TNNT1 TOLLIP TOX4 TRIM27 TRIM45 TUBB WDR77 ZBTB2 ZXDC	48 interacting genes: AANAT ABL1 AKT1 APP BAIAP2 BCR BLK CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 ERBB2 ERBB4 FARS2 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KANK2 KDR KIT KPNA3 MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NFKBID NOA1 PDGFRB PICK1 RAF1 RET SRC TEKT4 TEPSIN TNK1 TRIM55 TRIM63 TXK ZDHHC17 ZMYND19
Entrez ID		116225	2887
HPRD ID		15743	03312
Ensembl ID		ENSG00000165724	ENSG00000106070
Uniprot IDs		Q96E35	Q13322
PDB IDs			1NRV 3HK0
Enriched GO Terms of Interacting Partners?
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