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CMTM5 and PCNA
Data Source:
BioGRID
(two hybrid)
CMTM5
PCNA
Description
CKLF like MARVEL transmembrane domain containing 5
proliferating cell nuclear antigen
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Integral Component Of Membrane
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Chromatin
Nucleus
Nuclear Lamina
Nucleoplasm
Replication Fork
Centrosome
Nuclear Body
Replisome
Nuclear Replication Fork
PCNA Complex
Extracellular Exosome
PCNA-p21 Complex
Molecular Function
Cytokine Activity
Protein Binding
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
Chromatin Binding
Damaged DNA Binding
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Estrogen Receptor Binding
DNA Polymerase Processivity Factor Activity
Receptor Tyrosine Kinase Binding
Dinucleotide Insertion Or Deletion Binding
MutLalpha Complex Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Biological Process
Chemotaxis
Signal Transduction
Negative Regulation Of Myoblast Differentiation
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
Leading Strand Elongation
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Heart Development
Viral Process
Protein Ubiquitination
Translesion Synthesis
Epithelial Cell Differentiation
Replication Fork Processing
Positive Regulation Of Deoxyribonuclease Activity
Telomere Maintenance Via Semi-conservative Replication
Response To Estradiol
Nucleotide-excision Repair, DNA Incision
Cellular Response To UV
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Estrous Cycle
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Response To Cadmium Ion
Cellular Response To Hydrogen Peroxide
Error-free Translesion Synthesis
Cellular Response To Xenobiotic Stimulus
Response To Dexamethasone
Liver Regeneration
Positive Regulation Of DNA-directed DNA Polymerase Activity
Response To L-glutamate
Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Transcription of E2F targets under negative control by DREAM complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA replication proteins
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Liothyronine
Acetylsalicylic acid
Diseases
GWAS
Interacting Genes
131 interacting genes:
AACS
ABHD4
ACSF2
ACSM1
ALDH18A1
APOA1
APOA4
APOA5
AQP6
ARFIP1
ARFIP2
ARMC9
BIK
BNIP3
CAPNS2
CD160
CD40
CD79A
CLDN7
COQ8A
CPLX1
CPLX4
CREB3
CYP1A1
DDA1
DHRSX
ECPAS
ELOVL4
ERGIC3
FAM114A1
FARS2
FCGR2A
FCRL3
FERMT2
FFAR2
FNDC9
GAD1
GAD2
GJB1
GLTP
GOLGA2P10
GPX8
GTF3C1
HNRNPK
HSD17B13
JAGN1
JOSD2
KASH5
KCNJ6
KCNK5
KIR3DL3
LEUTX
LMNA
LMO2
LNX1
LRRC4C
LRRC59
MCEE
MCEMP1
MCFD2
MEOX2
MFF
MGST3
MIEF1
MRM1
MRRF
MTERF3
MTIF3
MYG1
NDRG4
NFU1
NTAQ1
PBX3
PCNA
PIMREG
PITPNC1
PLIN3
PNPO
POLL
PPIF
PPP2R3C
PSCA
PTPN9
RBFA
REEP2
RETREG3
RHBDD1
RMDN2
RNF185
RSRC2
RUSF1
SAR1A
SCARA5
SDCBP
SGCB
SH3GL1
SH3GLB1
SHMT2
SLC10A6
SLC18A2
SLC30A4
SLC35C2
SLC7A14
SNX1
SPATA8
SPG21
SSX3
SSX5
STING1
STOM
SUCLA2
SYNE4
SYT16
TBRG4
THAP4
TIMM44
TLCD4
TMED8
TMEM139
TMEM14B
TMEM35A
TMEM80
TMF1
TPD52L3
TSPAN31
TTPA
TUBB
TUFM
VARS2
ZNF391
ZNF599
139 interacting genes:
ALDOA
APEX1
APEX2
ATAD5
BAZ1B
CBX1
CCNB1
CCND1
CCND3
CCNO
CDC25C
CDC6
CDK1
CDK2
CDK5
CDK6
CDKN1A
CDKN1C
CDKN2A
CDT1
CHAF1A
CHTF18
CHTF8
CMTM5
CREBBP
DHX9
DNMT1
DNTT
DNTTIP2
DSCC1
DTL
EGFR
ENO1
EP300
ERCC5
ERCC6
ERRFI1
ESCO2
EXO1
FAN1
FANCD2
FANCL
FEN1
GADD45A
GADD45B
GADD45G
GAPDH
GCK
GPI
HDAC1
HUS1
HUWE1
IGF1R
ING1
KCTD13
KMT5A
LDHA
LIG1
LMNA
MCL1
MGMT
MLH1
MSH2
MSH3
MSH6
MUTYH
MYBBP1A
NMRAL1
NSD2
NTHL1
NUTF2
PARP1
PARP10
PARPBP
PCLAF
PFKM
PGAM1
PGK1
PKLR
PMS2
POLB
POLD1
POLD2
POLD3
POLD4
POLDIP2
POLE
POLH
POLI
POLK
POLL
POLM
PPP1CA
PRKDC
PTEN
PTMA
RAD18
RAD9A
RBBP8
RFC1
RFC2
RFC3
RFC4
RFC5
RFWD3
RNF8
RPA1
SDE2
SEC23IP
SIVA1
SLC30A8
SMARCAD1
SPG21
SUB1
SUMO1
TCOF1
TDG
TIRAP
TMEM218
TPI1
TRIM28
UBB
UBE2A
UBE2B
UBE2D3
UHRF1
UNG
USP1
USP2
USP4
WDR48
WRN
WRNIP1
XPA
XRCC1
XRCC5
XRCC6
YBX1
ZBTB1
Entrez ID
116173
5111
HPRD ID
06986
01456
Ensembl ID
ENSG00000166091
ENSG00000132646
Uniprot IDs
Q96DZ9
P12004
PDB IDs
1AXC
1U76
1U7B
1UL1
1VYJ
1VYM
1W60
2ZVK
2ZVL
2ZVM
3JA9
3P87
3TBL
3VKX
3WGW
4D2G
4RJF
4ZTD
5E0T
5E0U
5E0V
5IY4
5MAV
5MLO
5MLW
5MOM
5YCO
5YD8
6CBI
6EHT
6FCM
6FCN
6GIS
6GWS
6HVO
6K3A
6QC0
6QCG
6S1M
6S1N
6S1O
6TNY
6TNZ
6VVO
Enriched GO Terms of Interacting Partners
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