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CMTM5 and APOA1
Data Source:
BioGRID
(two hybrid, two hybrid, two hybrid)
CMTM5
APOA1
Description
CKLF like MARVEL transmembrane domain containing 5
apolipoprotein A1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Integral Component Of Membrane
Extracellular Region
Extracellular Space
Nucleus
Early Endosome
Endoplasmic Reticulum Lumen
Cytosol
Plasma Membrane
Cell Surface
Endocytic Vesicle
Cytoplasmic Vesicle
Very-low-density Lipoprotein Particle
Low-density Lipoprotein Particle
Intermediate-density Lipoprotein Particle
High-density Lipoprotein Particle
Discoidal High-density Lipoprotein Particle
Spherical High-density Lipoprotein Particle
Secretory Granule Lumen
Chylomicron
Collagen-containing Extracellular Matrix
Extracellular Exosome
Endocytic Vesicle Lumen
Blood Microparticle
Extracellular Vesicle
Molecular Function
Cytokine Activity
Protein Binding
Amyloid-beta Binding
Signaling Receptor Binding
Protein Binding
Phospholipid Binding
High-density Lipoprotein Particle Binding
Cholesterol Binding
Enzyme Binding
Heat Shock Protein Binding
Phosphatidylcholine Binding
Apolipoprotein Receptor Binding
Apolipoprotein A-I Receptor Binding
Identical Protein Binding
Chemorepellent Activity
Lipase Inhibitor Activity
Phosphatidylcholine-sterol O-acyltransferase Activator Activity
High-density Lipoprotein Particle Receptor Binding
Cholesterol Transfer Activity
Biological Process
Chemotaxis
Signal Transduction
Negative Regulation Of Myoblast Differentiation
Retinoid Metabolic Process
Regulation Of Protein Phosphorylation
Endothelial Cell Proliferation
Platelet Degranulation
Negative Regulation Of Cytokine Production Involved In Immune Response
Phosphatidylcholine Biosynthetic Process
Cholesterol Biosynthetic Process
Receptor-mediated Endocytosis
Transforming Growth Factor Beta Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Response To Nutrient
Cholesterol Metabolic Process
Glucocorticoid Metabolic Process
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Cholesterol Esterification
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Triglyceride Catabolic Process
Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling
Peripheral Nervous System Axon Regeneration
Protein Oxidation
Peptidyl-methionine Modification
Regulation Of Lipid Metabolic Process
Lipid Storage
Regulation Of Intestinal Cholesterol Absorption
Cholesterol Transport
Adrenal Gland Development
Animal Organ Regeneration
Regulation Of Cdc42 Protein Signal Transduction
Negative Regulation Of Interleukin-1 Beta Production
Cholesterol Efflux
Phospholipid Efflux
Negative Regulation Of Heterotypic Cell-cell Adhesion
Chylomicron Remodeling
Very-low-density Lipoprotein Particle Remodeling
High-density Lipoprotein Particle Remodeling
Chylomicron Assembly
High-density Lipoprotein Particle Assembly
High-density Lipoprotein Particle Clearance
Positive Regulation Of Rho Protein Signal Transduction
Lipoprotein Metabolic Process
Lipoprotein Biosynthetic Process
Response To Drug
Cholesterol Homeostasis
Blood Vessel Endothelial Cell Migration
Response To Estrogen
Post-translational Protein Modification
Reverse Cholesterol Transport
Cellular Protein Metabolic Process
Positive Regulation Of Fatty Acid Biosynthetic Process
Phosphatidylcholine Metabolic Process
Positive Regulation Of Lipid Biosynthetic Process
Negative Regulation Of Inflammatory Response
Positive Regulation Of Phagocytosis
Protein Stabilization
Negative Chemotaxis
Positive Regulation Of Lipoprotein Lipase Activity
Vitamin Transport
Positive Regulation Of Hydrolase Activity
Positive Regulation Of Stress Fiber Assembly
Transmembrane Transport
Phospholipid Homeostasis
Negative Regulation Of Lipase Activity
Negative Regulation Of Cell Adhesion Molecule Production
Negative Regulation Of Response To Cytokine Stimulus
Triglyceride Homeostasis
ERK1 And ERK2 Cascade
Cholesterol Import
Intermembrane Lipid Transfer
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Phospholipid Efflux
Pathways
Platelet degranulation
ABC transporters in lipid homeostasis
PPARA activates gene expression
Scavenging of heme from plasma
Scavenging by Class B Receptors
Scavenging by Class B Receptors
Scavenging by Class A Receptors
Scavenging by Class A Receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Defective ABCA1 causes TGD
Post-translational protein phosphorylation
Chylomicron assembly
HDL assembly
Chylomicron remodeling
HDL clearance
HDL remodeling
Retinoid metabolism and transport
Retinoid metabolism and transport
Amyloid fiber formation
Drugs
Zinc
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Hypoalphalipoproteinemia
Familial amyloidosis
GWAS
Allergic rhinitis (
30013184
)
Apolipoprotein A1 levels (
32203549
)
Blood protein levels (
29875488
)
Body mass index (
31978080
)
Cholesterol, total (
24097068
19060911
20686565
)
Coronary artery disease (
24262325
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Coronary heart disease (
21378990
)
Delirium (
29631748
)
Diastolic blood pressure (
27841878
)
Fasting triglyceride levels (
32603185
)
HDL cholesterol (
24097068
20864672
19060906
20686565
26582766
)
HDL cholesterol levels (
28334899
)
Hearing function (
25060954
)
Hematological and biochemical traits (
20139978
)
Hypertriglyceridemia (
27599772
23505323
)
Infantile hypertrophic pyloric stenosis (
23989729
)
LDL cholesterol (
24097068
18179892
20864672
19060911
20686565
)
LDL cholesterol levels (
28334899
)
Lipid metabolism phenotypes (
22286219
)
Lipid traits (
24386095
)
Metabolite levels (
22916037
)
Postprandial triglyceride levels (
32603185
)
Serum metabolite levels (
31636271
)
Serum metabolite levels (CMS) (
31636271
)
Systolic blood pressure (
27841878
)
Total cholesterol levels (
28334899
)
Total triglycerides levels (
26690388
)
Triglyceride levels (
28334899
26763881
28371326
28548082
)
Triglycerides (
24097068
19074352
21909109
18193043
18193044
18193046
20864672
19060906
19060911
20139978
20686565
26582766
)
Very low density lipoprotein cholesterol levels (
28548082
)
Interacting Genes
131 interacting genes:
AACS
ABHD4
ACSF2
ACSM1
ALDH18A1
APOA1
APOA4
APOA5
AQP6
ARFIP1
ARFIP2
ARMC9
BIK
BNIP3
CAPNS2
CD160
CD40
CD79A
CLDN7
COQ8A
CPLX1
CPLX4
CREB3
CYP1A1
DDA1
DHRSX
ECPAS
ELOVL4
ERGIC3
FAM114A1
FARS2
FCGR2A
FCRL3
FERMT2
FFAR2
FNDC9
GAD1
GAD2
GJB1
GLTP
GOLGA2P10
GPX8
GTF3C1
HNRNPK
HSD17B13
JAGN1
JOSD2
KASH5
KCNJ6
KCNK5
KIR3DL3
LEUTX
LMNA
LMO2
LNX1
LRRC4C
LRRC59
MCEE
MCEMP1
MCFD2
MEOX2
MFF
MGST3
MIEF1
MRM1
MRRF
MTERF3
MTIF3
MYG1
NDRG4
NFU1
NTAQ1
PBX3
PCNA
PIMREG
PITPNC1
PLIN3
PNPO
POLL
PPIF
PPP2R3C
PSCA
PTPN9
RBFA
REEP2
RETREG3
RHBDD1
RMDN2
RNF185
RSRC2
RUSF1
SAR1A
SCARA5
SDCBP
SGCB
SH3GL1
SH3GLB1
SHMT2
SLC10A6
SLC18A2
SLC30A4
SLC35C2
SLC7A14
SNX1
SPATA8
SPG21
SSX3
SSX5
STING1
STOM
SUCLA2
SYNE4
SYT16
TBRG4
THAP4
TIMM44
TLCD4
TMED8
TMEM139
TMEM14B
TMEM35A
TMEM80
TMF1
TPD52L3
TSPAN31
TTPA
TUBB
TUFM
VARS2
ZNF391
ZNF599
38 interacting genes:
ABCA1
ABCA13
AKT2
APOA2
APOB
APOC1
APOF
APOL1
APP
ATP5F1B
BRAP
CETP
CFHR1
CLEC4G
CMTM5
FBLN1
GPLD1
HP
HPR
JAK3
LBP
LCAT
MAP7D1
NAXE
NDRG1
PCMT1
PDE1A
PLTP
POLR1H
PON1
SAA2
SCARB1
SPP1
TNFRSF10C
TOMM20
TREM2
TTR
VKORC1
Entrez ID
116173
335
HPRD ID
06986
02517
Ensembl ID
ENSG00000166091
ENSG00000118137
Uniprot IDs
Q96DZ9
A0A024R3E3
P02647
PDB IDs
1AV1
1GW3
1GW4
1ODP
1ODQ
1ODR
2MSC
2MSD
2MSE
2N5E
3K2S
3R2P
4V6M
6CC9
6CCH
6CCX
6CLZ
6CM1
6PTS
6PTW
6W4E
6W4F
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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