TIRAP and DNAJC3

Data Source:
HPRD (in vivo)

		TIRAP	DNAJC3
Description		TIR domain containing adaptor protein	DnaJ heat shock protein family (Hsp40) member C3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Endocytic Vesicle Ruffle Membrane	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cytosol Membrane Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein-macromolecule Adaptor Activity Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Identical Protein Binding	Protein Kinase Inhibitor Activity Protein Kinase Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Negative Regulation Of Protein Kinase Activity Protein Folding In Endoplasmic Reticulum Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Defense Response To Virus Cellular Response To Cold Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4)	Viral mRNA Translation XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Neutrophil percentage of granulocytes ( 27863252)	Body mass index ( 28552196)
Interacting Genes		26 interacting genes: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK1 IRAK2 IRAK4 LRRK1 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1	7 interacting genes: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A HSPA5 THAP12 TIRAP
Entrez ID		114609	5611
HPRD ID		05878	03114
Ensembl ID		ENSG00000150455	ENSG00000102580
Uniprot IDs		A0A024R3M4 P58753	A8KA82 Q13217
PDB IDs		2NDH 2Y92 3UB2 3UB3 3UB4 4FZ5 4LQD 5T7Q 5UZB	2Y4T 2Y4U
Enriched GO Terms of Interacting Partners?
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