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TIRAP and IRAK2
Data Source:
HPRD
(in vivo)
TIRAP
IRAK2
Description
TIR domain containing adaptor protein
interleukin 1 receptor associated kinase 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Endocytic Vesicle
Ruffle Membrane
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Molecular Function
Protein Kinase C Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Protein-macromolecule Adaptor Activity
Toll-like Receptor 4 Binding
Toll-like Receptor 2 Binding
Identical Protein Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Biological Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Cell Surface Receptor Signaling Pathway
Activation Of NF-kappaB-inducing Kinase Activity
Myeloid Cell Differentiation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein-containing Complex Assembly
Response To Lipopolysaccharide
Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of ERK1 And ERK2 Cascade
3'-UTR-mediated MRNA Stabilization
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Positive Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Activation Of MAPK Activity
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Toll-like Receptor 9 Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Blood protein levels in cardiovascular risk (
28369058
)
Eosinophil percentage of granulocytes (
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Sum eosinophil basophil counts (
27863252
)
Interacting Genes
26 interacting genes:
APP
ARAF
BTK
CASP1
CCDC47
CD247
DNAJC3
EIF2AK2
IL1RL1
IRAK1
IRAK2
IRAK4
LRRK1
LTN1
MPP3
MYD88
PCNA
PRKRA
SAMHD1
SOCS1
TICAM1
TICAM2
TLR2
TLR4
TRAF6
TRAM1
20 interacting genes:
ARAF
HRAS
IL1R1
IRAK1
IRAK3
MYD88
PELI1
PELI2
PELI3
SARM1
SMAD2
SMURF1
STT3A
TARDBP
TICAM2
TIRAP
TLR4
TOLLIP
TRAF6
ZC3H12A
Entrez ID
114609
3656
HPRD ID
05878
04491
Ensembl ID
ENSG00000150455
ENSG00000134070
Uniprot IDs
A0A024R3M4
P58753
O43187
PDB IDs
2NDH
2Y92
3UB2
3UB3
3UB4
4FZ5
4LQD
5T7Q
5UZB
3MOP
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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