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TIRAP and TICAM1
Data Source:
HPRD
(in vivo)
TIRAP
TICAM1
Description
TIR domain containing adaptor protein
toll like receptor adaptor molecule 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Endocytic Vesicle
Ruffle Membrane
Mitochondrion
Autophagosome
Cytosol
Endosome Membrane
Ripoptosome
Molecular Function
Protein Kinase C Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Protein-macromolecule Adaptor Activity
Toll-like Receptor 4 Binding
Toll-like Receptor 2 Binding
Identical Protein Binding
Protein Binding
Protein Kinase Binding
Biological Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Cell Surface Receptor Signaling Pathway
Activation Of NF-kappaB-inducing Kinase Activity
Myeloid Cell Differentiation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein-containing Complex Assembly
Response To Lipopolysaccharide
Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of ERK1 And ERK2 Cascade
3'-UTR-mediated MRNA Stabilization
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Positive Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Macrophage Activation Involved In Immune Response
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
MyD88-independent Toll-like Receptor Signaling Pathway
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Viral Process
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Protein Binding
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Activation
Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein-containing Complex Assembly
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Necroptotic Process
Cellular Response To Lipopolysaccharide
Apoptotic Signaling Pathway
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Caspase activation via Death Receptors in the presence of ligand
MyD88-independent TLR4 cascade
Toll Like Receptor 3 (TLR3) Cascade
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TICAM1 deficiency - HSE
TRAF3 deficiency - HSE
TLR3-mediated TICAM1-dependent programmed cell death
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Blood protein levels in cardiovascular risk (
28369058
)
Eosinophil percentage of granulocytes (
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Medication use (thyroid preparations) (
31015401
)
Vitiligo (
27723757
22561518
)
Interacting Genes
26 interacting genes:
APP
ARAF
BTK
CASP1
CCDC47
CD247
DNAJC3
EIF2AK2
IL1RL1
IRAK1
IRAK2
IRAK4
LRRK1
LTN1
MPP3
MYD88
PCNA
PRKRA
SAMHD1
SOCS1
TICAM1
TICAM2
TLR2
TLR4
TRAF6
TRAM1
24 interacting genes:
AZI2
IKBKE
IRF3
IRF7
MAVS
PIAS4
PIK3CA
RIPK1
RIPK3
SRSF4
TBK1
TICAM2
TIRAP
TLR2
TLR3
TNFAIP3
TRAF1
TRAF2
TRAF3
TRAF4
TRAF6
TRAM1
TRIM8
UBQLN1
Entrez ID
114609
148022
HPRD ID
05878
06350
Ensembl ID
ENSG00000150455
ENSG00000127666
Uniprot IDs
A0A024R3M4
P58753
Q8IUC6
PDB IDs
2NDH
2Y92
3UB2
3UB3
3UB4
4FZ5
4LQD
5T7Q
5UZB
2M1X
2M63
3RC4
4BSX
4C0M
5JEL
Enriched GO Terms of Interacting Partners
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