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TIRAP
Description
TIR domain containing adaptor protein
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Endocytic Vesicle
Ruffle Membrane
Molecular Function
Protein Kinase C Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Protein-macromolecule Adaptor Activity
Toll-like Receptor 4 Binding
Toll-like Receptor 2 Binding
Identical Protein Binding
Biological Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Cell Surface Receptor Signaling Pathway
Activation Of NF-kappaB-inducing Kinase Activity
Myeloid Cell Differentiation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein-containing Complex Assembly
Response To Lipopolysaccharide
Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of ERK1 And ERK2 Cascade
3'-UTR-mediated MRNA Stabilization
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Positive Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Blood protein levels in cardiovascular risk (
28369058
)
Eosinophil percentage of granulocytes (
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Interacting Genes
26 interacting genes:
APP
ARAF
BTK
CASP1
CCDC47
CD247
DNAJC3
EIF2AK2
IL1RL1
IRAK1
IRAK2
IRAK4
LRRK1
LTN1
MPP3
MYD88
PCNA
PRKRA
SAMHD1
SOCS1
TICAM1
TICAM2
TLR2
TLR4
TRAF6
TRAM1
Entrez ID
114609
HPRD ID
05878
Ensembl ID
ENSG00000150455
Uniprot IDs
A0A024R3M4
P58753
PDB IDs
2NDH
2Y92
3UB2
3UB3
3UB4
4FZ5
4LQD
5T7Q
5UZB
Enriched GO Terms of Interacting Partners
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