DNAJC3 and THAP12

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DNAJC3	THAP12
Description		DnaJ heat shock protein family (Hsp40) member C3	THAP domain containing 12
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cytosol Membrane Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle	Nucleus
	Molecular Function	Protein Kinase Inhibitor Activity Protein Kinase Binding Chaperone Binding Misfolded Protein Binding	DNA Binding Protein Binding Metal Ion Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Protein Folding In Endoplasmic Reticulum Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Defense Response To Virus Cellular Response To Cold Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation	Signal Transduction Negative Regulation Of Cell Population Proliferation
Pathways		Viral mRNA Translation XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Body mass index ( 28552196)	Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433)
Interacting Genes		7 interacting genes: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A HSPA5 THAP12 TIRAP	10 interacting genes: DDX58 DNAJC3 EIF2AK2 EIF2S1 KIAA1958 MAPKAPK3 STK4 TACC1 TP53 ZNF526
Entrez ID		5611	5612
HPRD ID		03114	09567
Ensembl ID		ENSG00000102580	ENSG00000137492
Uniprot IDs		A8KA82 Q13217	A0A140VJQ7 O43422
PDB IDs		2Y4T 2Y4U
Enriched GO Terms of Interacting Partners?
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