PAFAH1B1 and HSPH1

Data Source:
HPRD (in vitro)

		PAFAH1B1	HSPH1
Description		platelet activating factor acetylhydrolase 1b regulatory subunit 1	heat shock protein family H (Hsp110) member 1
Image		No pdb structure
GO Annotations	Cellular Component	Astral Microtubule Kinetochore Nuclear Envelope Centrosome Cytosol Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Cell Leading Edge Motile Cilium Nuclear Membrane Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Axon Cytoplasm	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Protein-containing Complex Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Protein Heterodimerization Activity Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Alpha-tubulin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Acrosome Assembly Neuron Migration Microtubule-based Process Nuclear Migration Chemical Synaptic Transmission Germ Cell Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Regulation Of G2/M Transition Of Mitotic Cell Cycle Lipid Catabolic Process Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Reelin-mediated Signaling Pathway Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Microtubule Sliding Cell Division Ciliary Basal Body-plasma Membrane Docking Regulation Of Microtubule Motor Activity	Receptor-mediated Endocytosis Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of NK T Cell Activation Regulation Of Cellular Response To Heat
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Scavenging by Class F Receptors Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response
Drugs			Phenethyl Isothiocyanate
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Adverse response to drug ( 30420678) Mean platelet volume ( 32888494) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)	Metabolite levels ( 23823483)
Interacting Genes		22 interacting genes: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DNAI1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A	16 interacting genes: ADD1 CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 HSPA8 NMI PAFAH1B1 PAFAH1B3 PGK1 PTEN STK39 TUBA4A UBA1 VAV2
Entrez ID		5048	10808
HPRD ID		03329	09990
Ensembl ID		ENSG00000007168	ENSG00000120694
Uniprot IDs		A0A6Q8PFT2 A0A6Q8PFU3 P43034	A0A024RDQ0 A0A024RDS1 A0A0A0MSM0 B4DY72 Q92598
PDB IDs			6GFA
Enriched GO Terms of Interacting Partners?
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