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NCK2 and PAK2
Data Source:
BioGRID
(two hybrid)
NCK2
PAK2
Description
NCK adaptor protein 2
p21 (RAC1) activated kinase 2
Image
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum
Cytosol
Vesicle Membrane
Postsynaptic Density
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Postsynaptic Density
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Molecular Function
Phosphotyrosine Residue Binding
Protein Binding
Cytoskeletal Anchor Activity
Signaling Receptor Complex Adaptor Activity
Signaling Adaptor Activity
Protein-containing Complex Binding
Scaffold Protein Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Small GTPase Binding
Identical Protein Binding
Cadherin Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Immunological Synapse Formation
Actin Filament Organization
Signal Transduction
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Cell Population Proliferation
Cell Migration
Lamellipodium Assembly
Positive Regulation Of Actin Filament Polymerization
Negative Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendritic Spine Development
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Phosphorylation
Peptidyl-serine Phosphorylation
Stress-activated Protein Kinase Signaling Cascade
T Cell Costimulation
Activation Of Protein Kinase Activity
Adherens Junction Assembly
Interleukin-12-mediated Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Growth
Negative Regulation Of Apoptotic Process
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Axonogenesis
T Cell Receptor Signaling Pathway
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Dendritic Spine Development
Positive Regulation Of Protein Tyrosine Kinase Activity
Bicellular Tight Junction Assembly
Cellular Response To Organic Cyclic Compound
Protein Localization To Cell-cell Junction
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways
Downstream signal transduction
Nephrin family interactions
Ephrin signaling
Activation of RAC1
VEGFA-VEGFR2 Pathway
Regulation of cortical dendrite branching
Nef and signal transduction
Generation of second messenger molecules
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Stimulation of the cell death response by PAK-2p34
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Fostamatinib
Diseases
GWAS
Addiction (
23533358
)
Anti-chlamydia trachomatis IgG seropositivity (
33204752
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Systolic blood pressure in sickle cell anemia (
24058526
)
Asthma (
31959851
)
Atrial fibrillation (
29892015
)
Eosinophil counts (
32888494
27863252
)
Glucose homeostasis traits (
25524916
)
Lymphocyte counts (
32888494
27863252
)
Malaria (
31844061
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
27863252
)
Neutrophil count (
32888494
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Total ventricular volume (Alzheimer's disease interaction) (
21116278
)
White blood cell count (
32888494
27863252
)
Interacting Genes
171 interacting genes:
ABI1
ABI2
ABI3
ANKRD55
ANKS1B
ARHGAP32
ATN1
AXIN1
AXL
BCAR1
BCL11A
BTG1
C4orf17
CBARP
CBLB
CCDC120
CCDC33
CD3E
CHN1
CHN2
CIB1
CIPC
CLEC17A
CPSF6
CPSF7
CUEDC1
DDR1
DEFB124
DISC1
DLGAP4
DNM1
DOCK1
DOK1
DRAP1
DTX3
DVL1
EEF1G
EFHC2
EFNB1
EFNB2
EFS
EGFR
EIF3H
ERBB2
ERBB3
ERBB4
FAM124A
FAM47A
FAM53C
FAM83A
FASLG
FBXL19
FCRL2
FGFR1
FOSB
FXR2
FYB1
GAB1
GAREM1
GGN
HNRNPK
HOMEZ
HOXA1
HOXC4
HOXD8
HSF2BP
ILK
INCA1
INTS2
IRS1
KCTD17
KHDRBS1
KIAA0408
KIAA1217
KIT
KLHL24
KLHL35
KPRP
LCP2
LIMS1
LNX1
LRRIQ3
LZTS2
MAGEA6
MASP1
MBD6
MEOX2
MET
MIA3
MNT
MYPOP
NCKIPSD
NELFA
NET1
NFKBID
NHSL2
NPAS2
NPHS1
NR5A1
NTRK2
NUTM2F
ONECUT3
PAK1
PAK2
PBX4
PDGFRB
PHETA1
PIK3AP1
PKD1
PKN2
PRDM6
PRR16
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMD10
PTK2
RASSF7
RBBP8NL
RBM26
REEP4
REL
SCML2
SCX
SF1
SF3A2
SF3B4
SHD
SKAP2
SMARCB1
SNW1
SOCS7
SORBS2
SOS1
SPATA2L
SPATC1L
SPRY2
SRMS
SRPK1
SRPK2
SSH3
SYNGAP1
SYNPO
TCF4
TCP10L
TMEM121
TNR
TRIM27
TRIM41
TRIP6
TXK
UBC
USP32
VARS2
VPS37B
WAS
WASF1
WASL
WBP11
WIPF1
WIPF2
ZBTB12
ZBTB42
ZBTB7B
ZC2HC1A
ZC2HC1B
ZNF341
ZNF526
ZNF688
54 interacting genes:
ABI1
ABI2
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
DOCK2
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
H4C6
HCK
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NCK2
NPHP1
PACSIN3
PPM1A
RAC1
RAC2
RAF1
RHOJ
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
Entrez ID
8440
5062
HPRD ID
05378
05428
Ensembl ID
ENSG00000071051
ENSG00000180370
Uniprot IDs
A0A0S2Z4M6
E7ERP6
O43639
A8K5M4
Q13177
PDB IDs
1U5S
1WX6
1Z3K
2B86
2CIA
2FRW
2FRY
2JXB
4E6R
3PCS
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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