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NCK2 and DLGAP4
Data Source:
BioGRID
(two hybrid)
NCK2
DLGAP4
Description
NCK adaptor protein 2
DLG associated protein 4
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum
Cytosol
Vesicle Membrane
Postsynaptic Density
Plasma Membrane
Neuromuscular Junction
Glutamatergic Synapse
Cholinergic Synapse
Postsynaptic Specialization
Molecular Function
Phosphotyrosine Residue Binding
Protein Binding
Cytoskeletal Anchor Activity
Signaling Receptor Complex Adaptor Activity
Signaling Adaptor Activity
Protein-containing Complex Binding
Scaffold Protein Binding
Protein Binding
Molecular Adaptor Activity
Biological Process
Immunological Synapse Formation
Actin Filament Organization
Signal Transduction
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Cell Population Proliferation
Cell Migration
Lamellipodium Assembly
Positive Regulation Of Actin Filament Polymerization
Negative Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendritic Spine Development
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Signaling
Regulation Of Postsynaptic Neurotransmitter Receptor Activity
Pathways
Downstream signal transduction
Nephrin family interactions
Ephrin signaling
Activation of RAC1
VEGFA-VEGFR2 Pathway
Regulation of cortical dendrite branching
Neurexins and neuroligins
Neurexins and neuroligins
Drugs
Diseases
GWAS
Addiction (
23533358
)
Anti-chlamydia trachomatis IgG seropositivity (
33204752
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Systolic blood pressure in sickle cell anemia (
24058526
)
Low density lipoprotein cholesterol levels (
32154731
)
Neuroblastoma or malignant cutaneous melanoma (
31605138
)
Interacting Genes
171 interacting genes:
ABI1
ABI2
ABI3
ANKRD55
ANKS1B
ARHGAP32
ATN1
AXIN1
AXL
BCAR1
BCL11A
BTG1
C4orf17
CBARP
CBLB
CCDC120
CCDC33
CD3E
CHN1
CHN2
CIB1
CIPC
CLEC17A
CPSF6
CPSF7
CUEDC1
DDR1
DEFB124
DISC1
DLGAP4
DNM1
DOCK1
DOK1
DRAP1
DTX3
DVL1
EEF1G
EFHC2
EFNB1
EFNB2
EFS
EGFR
EIF3H
ERBB2
ERBB3
ERBB4
FAM124A
FAM47A
FAM53C
FAM83A
FASLG
FBXL19
FCRL2
FGFR1
FOSB
FXR2
FYB1
GAB1
GAREM1
GGN
HNRNPK
HOMEZ
HOXA1
HOXC4
HOXD8
HSF2BP
ILK
INCA1
INTS2
IRS1
KCTD17
KHDRBS1
KIAA0408
KIAA1217
KIT
KLHL24
KLHL35
KPRP
LCP2
LIMS1
LNX1
LRRIQ3
LZTS2
MAGEA6
MASP1
MBD6
MEOX2
MET
MIA3
MNT
MYPOP
NCKIPSD
NELFA
NET1
NFKBID
NHSL2
NPAS2
NPHS1
NR5A1
NTRK2
NUTM2F
ONECUT3
PAK1
PAK2
PBX4
PDGFRB
PHETA1
PIK3AP1
PKD1
PKN2
PRDM6
PRR16
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMD10
PTK2
RASSF7
RBBP8NL
RBM26
REEP4
REL
SCML2
SCX
SF1
SF3A2
SF3B4
SHD
SKAP2
SMARCB1
SNW1
SOCS7
SORBS2
SOS1
SPATA2L
SPATC1L
SPRY2
SRMS
SRPK1
SRPK2
SSH3
SYNGAP1
SYNPO
TCF4
TCP10L
TMEM121
TNR
TRIM27
TRIM41
TRIP6
TXK
UBC
USP32
VARS2
VPS37B
WAS
WASF1
WASL
WBP11
WIPF1
WIPF2
ZBTB12
ZBTB42
ZBTB7B
ZC2HC1A
ZC2HC1B
ZNF341
ZNF526
ZNF688
32 interacting genes:
ABI2
ALDH16A1
ATPAF2
BIN1
DLG1
DLG3
DLG4
EXOC4
FHL3
FHL5
FKBP6
FYN
GRIN1
GRIN2D
MAGEA6
MPP7
MTUS2
NCK1
NCK2
PALS1
PLP2
PPP1R1B
SH3GL2
SH3RF1
SHANK2
SHANK3
SLC9A3R1
SLC9A3R2
SORBS2
SYNGAP1
UBASH3A
UBC
Entrez ID
8440
22839
HPRD ID
05378
16826
Ensembl ID
ENSG00000071051
ENSG00000080845
Uniprot IDs
A0A0S2Z4M6
E7ERP6
O43639
A0A0B4J2C2
Q9Y2H0
PDB IDs
1U5S
1WX6
1Z3K
2B86
2CIA
2FRW
2FRY
2JXB
4E6R
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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