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CCDC85B and CDKN1A
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
CCDC85B
CDKN1A
Description
coiled-coil domain containing 85B
cyclin dependent kinase inhibitor 1A
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Centrosome
Adherens Junction
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Nuclear Body
Protein-containing Complex
Perinuclear Region Of Cytoplasm
PCNA-p21 Complex
Molecular Function
Protein Binding
Delta-catenin Binding
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Cyclin-dependent Protein Kinase Activating Kinase Activity
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Sequestering Activity
Biological Process
Viral Process
Cell Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Import Into Nucleus
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Cell Cycle Arrest
Mitotic G2 DNA Damage Checkpoint
Ras Protein Signal Transduction
Heart Development
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Response To X-ray
Response To Organonitrogen Compound
Negative Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Negative Regulation Of Cell Growth
Positive Regulation Of B Cell Proliferation
Animal Organ Regeneration
Cellular Response To Extracellular Stimulus
Negative Regulation Of Protein Binding
Cellular Response To Amino Acid Starvation
Cellular Response To Heat
Wound Healing
Tissue Regeneration
Negative Regulation Of Phosphorylation
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Response To Arsenic-containing Substance
Positive Regulation Of Fibroblast Proliferation
Protein Stabilization
Response To Corticosterone
Response To Hyperoxia
Intestinal Epithelial Cell Maturation
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-B
Mitotic Cell Cycle Arrest
Cellular Senescence
Replicative Senescence
Stress-induced Premature Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Positive Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Transcriptional regulation by RUNX2
RUNX3 regulates CDKN1A transcription
Transcriptional regulation of granulopoiesis
FOXO-mediated transcription of cell cycle genes
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Drugs
Arsenic trioxide
Diseases
Cervical cancer
GWAS
Acne (severe) (
24927181
)
Asthma (
31959851
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
22634755
30529582
31826910
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
32602732
20062063
)
Glaucoma (primary open-angle) (
29891935
)
Heart failure (
31919418
)
Ischemic stroke (
29531354
)
JT interval (
29874175
)
Left ventricular fractional shortening (
28394258
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
QRS complex (Cornell) (
27659466
)
QRS duration (
30679814
27577874
31251759
25035420
31217584
21076409
27659466
)
Triglyceride levels (
32203549
)
Triglycerides (
27036123
)
Interacting Genes
138 interacting genes:
AGGF1
AKAP17A
AKIRIN2
APEX2
AQP1
BEX2
BEX3
BIRC5
C19orf25
C21orf91
C2CD6
C7orf50
C8orf48
CARD9
CCDC112
CCDC116
CCDC120
CCDC185
CCDC33
CCNK
CDK18
CDKN1A
CENPP
CEP70
CFAP53
CHCHD3
COPS4
CWC25
DEPP1
DEUP1
DOK5
DTNB
DUSP13
EIF3H
ENKD1
EPS8
EXOC7
EXOC8
EZH2
FAM107A
FAM124B
FAM13C
FAM214B
FAM27E3
FAM50B
FAM74A4
FASTKD5
FBF1
FCHSD2
FNDC11
FXR2
GCC1
GFI1B
GPANK1
HMG20B
HNRNPC
IKZF5
INO80B
KANSL1
KIAA0408
KRT17
KRT18
KRT20
KRT6A
LDOC1
LMO3
LNX1
LZTS2
MBIP
MCM10
MCRS1
MEAF6
MOAP1
MOB1A
MOB4
NDUFA5
NEK6
NIF3L1
NRIP1
NUP54
ODAD4
PBXIP1
PIDD1
PKN1
PLEKHF2
PLOD3
POLR2L
PRC1
PRPF3
PSMA1
PSMC1
PSMC6
PSMF1
RALYL
RBM41
RBM7
RGS8
RIBC2
RNF8
SCNM1
SETD5
SF3A3
SIX1
SLU7
SMARCD1
SPATA46
SYT17
SYTL4
TASOR2
TCEANC
TCHP
TEAD4
THAP7
TNNI1
TNNT1
TSPYL4
TTC14
TUBGCP4
USP2
UTP14A
UTP6
VPS72
ZBTB16
ZBTB5
ZC2HC1C
ZFC3H1
ZFP36
ZNF165
ZNF205
ZNF250
ZNF337
ZNF417
ZNF426
ZNF564
ZNF587
ZNF638
ZNF764
ZNF821
205 interacting genes:
A1BG
A2M
ABL1
ACTB
ACTL6B
ADAMTS10
AKT1
AKT2
ALAS1
ANGPT2
APLP1
APP
ATP5F1B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
CASP3
CCDC85B
CCN3
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHEK2
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
CZIB
DAPK3
DCAF11
DDAH2
DEAF1
DOCK7
DTL
DYNC1I1
EEF1A1
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FHL3
FLAD1
FNDC11
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB5
GOLGA2
H1-5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HMGXB3
HNRNPK
HOOK2
HOXD8
HPD
IKBKG
IKZF3
INCA1
ING5
INPP5K
KIFC3
KLHL23
KMT2B
KRT31
KRTAP3-1
LATS2
LRIF1
LRP2BP
LRR1
LZTS2
MAP3K5
MAPK8
MCM10
MED31
MEOX2
MSH2
MTUS2
NFYA
NGFR
NKD2
NMRK2
NPRL2
NR1H2
NRBP1
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
PKM
POLD2
PRKACA
PRKAR1B
PRKN
PSMA3
PSMC2
QARS1
RAB1A
RACK1
RAI1
RB1
RBBP4
RBM48
REL
RNF126
RNF144B
RPL18
RPL35
RPS2
RRM2B
S100A8
SDF4
SET
SETDB1
SHISA6
SIPA1
SKP1
SKP2
SLC25A11
SP110
SPRED1
STAT3
STAT5B
STUB1
SUMO3
TAF5L
TCF4
TEX11
TFIP11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TP53
TRAF1
TRIM3
TRIM54
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBE2D1
UNC119
USHBP1
USP11
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
Entrez ID
11007
1026
HPRD ID
16101
00298
Ensembl ID
ENSG00000175602
ENSG00000124762
Uniprot IDs
Q15834
A0A024RCX5
P38936
PDB IDs
1AXC
2ZVV
2ZVW
4RJF
5E0U
6CBI
6CEJ
6CIV
6CIX
6P8H
Enriched GO Terms of Interacting Partners
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