CDKN1A and MED31

Data Source:
BioGRID (two hybrid)

		CDKN1A	MED31
Description		cyclin dependent kinase inhibitor 1A	mediator complex subunit 31
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body Protein-containing Complex Perinuclear Region Of Cytoplasm PCNA-p21 Complex	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Cyclin-dependent Protein Kinase Activating Kinase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding Protein Sequestering Activity	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Import Into Nucleus Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Mitotic G2 DNA Damage Checkpoint Ras Protein Signal Transduction Heart Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Response To X-ray Response To Organonitrogen Compound Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Animal Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Cellular Response To Amino Acid Starvation Cellular Response To Heat Wound Healing Tissue Regeneration Negative Regulation Of Phosphorylation Response To Drug Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Arsenic-containing Substance Positive Regulation Of Fibroblast Proliferation Protein Stabilization Response To Corticosterone Response To Hyperoxia Intestinal Epithelial Cell Maturation Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Mitotic Cell Cycle Arrest Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Fibroblast Proliferation Limb Development
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Arsenic trioxide
Diseases		Cervical cancer
GWAS		Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 22634755 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 32602732 20062063) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Ischemic stroke ( 29531354) JT interval ( 29874175) Left ventricular fractional shortening ( 28394258) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 30679814 27577874 31251759 25035420 31217584 21076409 27659466) Triglyceride levels ( 32203549) Triglycerides ( 27036123)	LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		205 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 FNDC11 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 GOLGA2 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOOK2 HOXD8 HPD IKBKG IKZF3 INCA1 ING5 INPP5K KIFC3 KLHL23 KMT2B KRT31 KRTAP3-1 LATS2 LRIF1 LRP2BP LRR1 LZTS2 MAP3K5 MAPK8 MCM10 MED31 MEOX2 MSH2 MTUS2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 PKM POLD2 PRKACA PRKAR1B PRKN PSMA3 PSMC2 QARS1 RAB1A RACK1 RAI1 RB1 RBBP4 RBM48 REL RNF126 RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SDF4 SET SETDB1 SHISA6 SIPA1 SKP1 SKP2 SLC25A11 SP110 SPRED1 STAT3 STAT5B STUB1 SUMO3 TAF5L TCF4 TEX11 TFIP11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TP53 TRAF1 TRIM3 TRIM54 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USHBP1 USP11 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431	59 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1
Entrez ID		1026	51003
HPRD ID		00298	14382
Ensembl ID		ENSG00000124762	ENSG00000108590
Uniprot IDs		A0A024RCX5 P38936	Q9Y3C7
PDB IDs		1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX 6P8H
Enriched GO Terms of Interacting Partners?
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