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CDKN1A and VIM
Data Source:
BioGRID
(two hybrid)
CDKN1A
VIM
Description
cyclin dependent kinase inhibitor 1A
vimentin
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Nuclear Body
Protein-containing Complex
Perinuclear Region Of Cytoplasm
PCNA-p21 Complex
Cytoplasm
Peroxisome
Cytosol
Polysome
Cytoskeleton
Intermediate Filament
Plasma Membrane
Focal Adhesion
Nuclear Matrix
Cell Leading Edge
Neuron Projection
Intermediate Filament Cytoskeleton
Phagocytic Vesicle
Extracellular Exosome
Ribonucleoprotein Complex
Molecular Function
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Cyclin-dependent Protein Kinase Activating Kinase Activity
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Sequestering Activity
Double-stranded RNA Binding
Structural Constituent Of Cytoskeleton
Structural Constituent Of Eye Lens
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Scaffold Protein Binding
Keratin Filament Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Import Into Nucleus
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Cell Cycle Arrest
Mitotic G2 DNA Damage Checkpoint
Ras Protein Signal Transduction
Heart Development
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Response To X-ray
Response To Organonitrogen Compound
Negative Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Negative Regulation Of Cell Growth
Positive Regulation Of B Cell Proliferation
Animal Organ Regeneration
Cellular Response To Extracellular Stimulus
Negative Regulation Of Protein Binding
Cellular Response To Amino Acid Starvation
Cellular Response To Heat
Wound Healing
Tissue Regeneration
Negative Regulation Of Phosphorylation
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Response To Arsenic-containing Substance
Positive Regulation Of Fibroblast Proliferation
Protein Stabilization
Response To Corticosterone
Response To Hyperoxia
Intestinal Epithelial Cell Maturation
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-B
Mitotic Cell Cycle Arrest
Cellular Senescence
Replicative Senescence
Stress-induced Premature Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Positive Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Neuron Projection Development
Astrocyte Development
Viral Process
Cytokine-mediated Signaling Pathway
Muscle Filament Sliding
Positive Regulation Of Collagen Biosynthetic Process
Regulation Of MRNA Stability
Intermediate Filament Organization
Positive Regulation Of Translation
Bergmann Glial Cell Differentiation
SMAD Protein Signal Transduction
Lens Fiber Cell Development
Cellular Response To Lipopolysaccharide
Cellular Response To Muramyl Dipeptide
Cellular Response To Interferon-gamma
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Transcriptional regulation by RUNX2
RUNX3 regulates CDKN1A transcription
Transcriptional regulation of granulopoiesis
FOXO-mediated transcription of cell cycle genes
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Caspase-mediated cleavage of cytoskeletal proteins
Striated Muscle Contraction
Interleukin-4 and Interleukin-13 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Drugs
Arsenic trioxide
Artenimol
Phenethyl Isothiocyanate
Diseases
Cervical cancer
GWAS
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
22634755
30529582
31826910
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
32602732
20062063
)
Glaucoma (primary open-angle) (
29891935
)
Heart failure (
31919418
)
Ischemic stroke (
29531354
)
JT interval (
29874175
)
Left ventricular fractional shortening (
28394258
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
QRS complex (Cornell) (
27659466
)
QRS duration (
30679814
27577874
31251759
25035420
31217584
21076409
27659466
)
Triglyceride levels (
32203549
)
Triglycerides (
27036123
)
Cholesterol, total (
24097068
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Total cholesterol levels (
28334899
)
Triglyceride levels (
32203549
)
Interacting Genes
205 interacting genes:
A1BG
A2M
ABL1
ACTB
ACTL6B
ADAMTS10
AKT1
AKT2
ALAS1
ANGPT2
APLP1
APP
ATP5F1B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
CASP3
CCDC85B
CCN3
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHEK2
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
CZIB
DAPK3
DCAF11
DDAH2
DEAF1
DOCK7
DTL
DYNC1I1
EEF1A1
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FHL3
FLAD1
FNDC11
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB5
GOLGA2
H1-5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HMGXB3
HNRNPK
HOOK2
HOXD8
HPD
IKBKG
IKZF3
INCA1
ING5
INPP5K
KIFC3
KLHL23
KMT2B
KRT31
KRTAP3-1
LATS2
LRIF1
LRP2BP
LRR1
LZTS2
MAP3K5
MAPK8
MCM10
MED31
MEOX2
MSH2
MTUS2
NFYA
NGFR
NKD2
NMRK2
NPRL2
NR1H2
NRBP1
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
PKM
POLD2
PRKACA
PRKAR1B
PRKN
PSMA3
PSMC2
QARS1
RAB1A
RACK1
RAI1
RB1
RBBP4
RBM48
REL
RNF126
RNF144B
RPL18
RPL35
RPS2
RRM2B
S100A8
SDF4
SET
SETDB1
SHISA6
SIPA1
SKP1
SKP2
SLC25A11
SP110
SPRED1
STAT3
STAT5B
STUB1
SUMO3
TAF5L
TCF4
TEX11
TFIP11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TP53
TRAF1
TRIM3
TRIM54
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBE2D1
UNC119
USHBP1
USP11
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
171 interacting genes:
ABLIM1
AKT1
ANKRD35
ANXA7
APIP
APLP1
APP
ARMC7
ARMCX2
ATN1
BFSP1
BHLHE40
BRD1
BYSL
C2CD6
CAMK2D
CAPN1
CASP3
CASP6
CASP7
CASP8
CASP9
CBX8
CCDC187
CDH5
CDK1
CDKN1A
CEP126
CHD3
COPS6
CRCT1
CREB1
CRMP1
CT55
CWF19L2
DCTN1
DEFB1
DES
DIS3L2
DNM1L
DPPA4
DSP
DUX4
DYNLL1
ENTR1
ESS2
FABP4
FAM107A
FAM118B
FAM161A
FUBP1
GADD45A
GEM
GFAP
GOPC
GRB2
GSK3B
HABP4
HAP1
HMG20B
HSPB1
HTRA2
ING5
IP6K1
ITGB4
IVNS1ABP
KARS1
KAT7
KIAA0408
KIF15
KIF9
KIFC3
KRT20
KRT75
LGALS14
LINC01554
LORICRIN
LRIF1
MAFG
MAN2A2
MCPH1
MEN1
MICAL1
MRPL44
MTDH
NEFL
NEFM
NFATC2
NFKBID
NIF3L1
NME2
NOC4L
NR1H2
NUP85
OSBP2
PAK2
PDLIM1
PIAS4
PKD1
PKN1
PKP1
PLA2G2A
PLA2G4A
PLEC
PNMA5
POLR1C
PPHLN1
PPL
PPP1R18
PRKACA
PRPH
PSMA1
PSMC5
PSMD7
PSME1
PUF60
RAB8B
RABAC1
RAD51
RBM48
RIBC2
ROCK1
RPA1
SCNM1
SERBP1
SETDB1
SH3GL1
SH3GL3
SH3YL1
SIRPA
SIRT6
SLC25A6
SLC27A6
SMAD3
SMARCB1
SRRT
STK19
STX1A
SUMO2
SUMO3
SYN1
TAB2
TCEA2
TCHP
TLE5
TNFRSF14
TNNT1
TRIM14
TRIM15
TRIM28
TRIM29
TRIOBP
TSC22D1
TTR
TUBA1C
TUBGCP4
TXLNB
TXN
TXN2
UPP1
UPP2
UROD
UTP14A
WBP11
XRCC4
YAE1
YWHAE
YWHAZ
ZHX1
ZNF384
ZNF572
Entrez ID
1026
7431
HPRD ID
00298
01899
Ensembl ID
ENSG00000124762
ENSG00000026025
Uniprot IDs
A0A024RCX5
P38936
P08670
V9HWE1
PDB IDs
1AXC
2ZVV
2ZVW
4RJF
5E0U
6CBI
6CEJ
6CIV
6CIX
6P8H
1GK4
1GK6
1GK7
3G1E
3KLT
3S4R
3SSU
3SWK
3TRT
3UF1
4MCY
4MCZ
4MD0
4MD5
4MDI
4MDJ
4YPC
4YV3
5WHF
6ATF
6ATI
6BIR
Enriched GO Terms of Interacting Partners
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