SEC61B and MORC3

Data Source:
BioGRID (affinity chromatography technology)

		SEC61B	MORC3
Description		SEC61 translocon subunit beta	MORC family CW-type zinc finger 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Nucleoplasm Nuclear Matrix PML Body
	Molecular Function	RNA Binding Protein Binding Epidermal Growth Factor Binding	RNA Binding Protein Binding Zinc Ion Binding Methylated Histone Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation Regulation Of Catalytic Activity	Protein Phosphorylation Cell Aging Post-embryonic Development Viral Process Peptidyl-serine Phosphorylation Negative Regulation Of Fibroblast Proliferation Protein Stabilization Maintenance Of Protein Location In Nucleus
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Diastolic blood pressure ( 30224653) Height ( 31562340)
Interacting Genes		19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1 UBL4A	5 interacting genes: ERCC6 KPNA2 RNF216 SUMO2 UBC
Entrez ID		10952	23515
HPRD ID		06715	10316
Ensembl ID		ENSG00000106803	ENSG00000159256
Uniprot IDs		P60468	B4DHJ4 Q14149 Q4VBZ9
PDB IDs		6W6L	4QQ4 5SVI 5SVX 5SVY 6O1E 6O5W
Enriched GO Terms of Interacting Partners?
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