TRAF3IP2 and TRAF5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		TRAF3IP2	TRAF5
Description		TRAF3 interacting protein 2	TNF receptor associated factor 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component	Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Signaling Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding
	Biological Process	B Cell Apoptotic Process Positive Regulation Of Defense Response To Virus By Host Inflammatory Response Humoral Immune Response Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein K63-linked Ubiquitination Interleukin-17-mediated Signaling Pathway	Apoptotic Process Signal Transduction Positive Regulation Of Cell Population Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS		Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Inflammatory bowel disease ( 28067908 23128233) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Psoriasis ( 25903422 20953188 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)	Household income (MTAG) ( 31844048)
Interacting Genes		23 interacting genes: CD40 CHUK FHL3 GOLGA2 HSD17B10 IKBKB IKBKG MAP3K7 MDFI MRPL28 RIMBP3 STK16 TBK1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 TRIP6 UBC UBE2V1	66 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 CDC37 CIB3 COG7 COMMD3 DGKH ENOX2 FAM9A FBXO28 GAS8 GOLGA2 GORASP2 HOMER1 HSD17B10 HSF2BP LMO4 LNX1 LTBR MAP3K14 MAP3K5 MDM2 MEOX2 NMI NTAQ1 NUMBL ODF2 PIAS2 PIBF1 PICK1 PSMA1 RAD23A RIPK1 RIPK2 RNF111 RNF4 SDCBP SEC13 SERPINB9 SUMO1 TBK1 TDP2 THAP1 THAP7 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 YPEL5 ZFAND6 ZNF655
Entrez ID		10758	7188
HPRD ID		06129	03834
Ensembl ID		ENSG00000056972	ENSG00000082512
Uniprot IDs		O43734	O00463
PDB IDs
Enriched GO Terms of Interacting Partners?
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