CYLD and AURKB

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CYLD	AURKB
Description		CYLD lysine 63 deubiquitinase	aurora kinase B
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GO Annotations	Cellular Component	Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip	Kinetochore Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Midzone
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding Protein Kinase Binding Lys63-specific Deubiquitinase Activity Proline-rich Region Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Binding Histone Serine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Innate Immune Response Negative Regulation Of JNK Cascade Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling Regulation Of Cilium Assembly Negative Regulation Of P38MAPK Cascade Protein Linear Deubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Spindle Organization Mitotic Spindle Organization Mitotic Spindle Assembly Checkpoint Aging Cell Population Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytokinesis Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Histone H3-S28 Phosphorylation Mitotic Cytokinesis Checkpoint Protein Autophosphorylation Mitotic Spindle Midzone Assembly Positive Regulation Of Telomerase Activity Regulation Of Chromosome Segregation Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomere Capping Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Regulation of TP53 Activity through Phosphorylation Mitotic Prometaphase Regulation of MECP2 expression and activity EML4 and NUDC in mitotic spindle formation
Drugs			Hesperidin AT9283 Enzastaurin Reversine Fostamatinib
Diseases		Familial cylindromatosis Multiple familial trichoepithelioma Brooke-Spiegler syndrome
GWAS		Adventurousness ( 30643258) Asthma (childhood onset) ( 31036433) Asthma (time to onset) ( 27130862) Body mass index ( 28892062) Crohn's disease ( 28067908 22412388) Femoral neck bone mineral density ( 29499414) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Leprosy ( 25642632 22019778) Lumbar spine bone mineral density ( 29499414 22504420)	Anxiety disorders ( 31906708) Apolipoprotein A1 levels ( 32203549)
Interacting Genes		23 interacting genes: AKT1 AURKB DDX58 DLG4 HDAC6 IKBKE IKBKG ITCH MAP3K7 MAPRE1 PLK4 PTPA TBK1 TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM47 TUBA1A UBC UBE2D2 UBE2S	52 interacting genes: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP H3-4 H3C1 H3C14 HASPIN INCENP KLHL13 KLHL21 KLHL9 LATS1 LATS2 LNX1 LRRK2 MAPRE1 MAPRE2 MAPRE3 MFHAS1 NCAPH NDC80 NINL NSUN2 NUF2 PKM PSMA3 PTPA RACGAP1 RACK1 RAD52 RASA1 RASSF1 SEPTIN1 SKA1 SKA3 TACC1 TBL3 TGFBR1 UBE2I
Entrez ID		1540	9212
HPRD ID		05427	05397
Ensembl ID		ENSG00000083799	ENSG00000178999
Uniprot IDs		A0A024R6T1 Q9NQC7	Q96GD4
PDB IDs		1IXD 1WHL 1WHM 2VHF	4AF3
Enriched GO Terms of Interacting Partners?
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