AP4B1 and BUB1B

Data Source:
HPRD (two hybrid)

		AP4B1	BUB1B
Description		adaptor related protein complex 4 subunit beta 1	BUB1 mitotic checkpoint serine/threonine kinase B
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GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Extrinsic Component Of Membrane AP-4 Adaptor Complex Clathrin Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome Outer Kinetochore Anaphase-promoting Complex Cytoplasm Microtubule Organizing Center Spindle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Clathrin Binding	Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Targeting Protein Localization Vesicle-mediated Transport	Mitotic Cell Cycle Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Catabolic Process Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Cerebral palsy
GWAS		Alopecia areata ( 25608926) Breast cancer ( 23535729) Crohn's disease ( 28067908) Mean corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Chronic lymphocytic leukemia ( 28165464 24292274)
Interacting Genes		6 interacting genes: AP4E1 AP4M1 BUB1 BUB1B TEPSIN ZNF576	26 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DNMBP FBXO7 FZR1 HDAC1 KNL1 MAP3K4 PELI1 PLK1 RIPK3 SNCG TP73 TRIP13
Entrez ID		10717	701
HPRD ID		06259	04176
Ensembl ID		ENSG00000134262	ENSG00000156970
Uniprot IDs		A0A024R0J5 B1ALD0 B3KSJ4 B4DTG3 Q9Y6B7	O60566
PDB IDs		2MJ7	2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ
Enriched GO Terms of Interacting Partners?
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