ADCY1 and FZD7

Data Source:
BioGRID (two hybrid)

		ADCY1	FZD7
Description		adenylate cyclase 1	frizzled class receptor 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Raft Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane
	Molecular Function	Adenylate Cyclase Activity Calmodulin Binding ATP Binding Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Metal Ion Binding	G Protein-coupled Receptor Activity Frizzled Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity
	Biological Process	Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Axonogenesis Brain Development Long-term Memory Circadian Rhythm Response To Lithium Ion CAMP-mediated Signaling Positive Regulation Of CREB Transcription Factor Activity Activation Of Protein Kinase A Activity Response To Drug Regulation Of Circadian Rhythm Cellular Response To Calcium Ion Cellular Response To Glucagon Stimulus Neuroinflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Cellular Response To Forskolin Regulation Of Synaptic Vesicle Exocytosis	Regulation Of Transcription, DNA-templated G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell-substrate Adhesion Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Stem Cell Population Maintenance Neuron Differentiation T Cell Differentiation In Thymus Substrate Adhesion-dependent Cell Spreading Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Positive Regulation Of Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Somatic Stem Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesenchymal To Epithelial Transition Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Retinoic Acid Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis	Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs		Adenosine phosphate ATP Aurothioglucose
Diseases
GWAS		Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Night sleep phenotypes ( 27126917) Subjective response to lithium treatment in bipolar disorder ( 26503763)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549 28869591) Metabolite levels ( 23823483) Risk-taking tendency (4-domain principal component model) ( 30643258) Total body bone mineral density ( 29304378)
Interacting Genes		4 interacting genes: ADCY2 FZD7 GNAI2 SERTAD1	28 interacting genes: ADCY1 AIG1 AQP9 BCL2L13 CLN8 CLPTM1 DLG1 DLG2 DLG4 FFAR2 GNAS HPCAL1 LEUTX MAGI3 MGST1 NCALD NCS1 PDAP1 PRNP PSME3IP1 SGTA SGTB SLC30A4 SLC35B1 TMEM237 UBQLN1 UBQLN2 UBQLN4
Entrez ID		107	8324
HPRD ID		00053	04560
Ensembl ID		ENSG00000164742	ENSG00000155760
Uniprot IDs		C9J1J0 Q08828	O75084
PDB IDs			4Z33 5T44 5URV 5WBS 6NE2 6NE4 6O3A 6O3B
Enriched GO Terms of Interacting Partners?
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