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SPAG5 and PLK4
Data Source:
BioGRID
(two hybrid)
SPAG5
PLK4
Description
sperm associated antigen 5
polo like kinase 4
Image
No pdb structure
GO Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Cytoplasm
Cytosol
Nuclear Body
Midbody
Centriolar Satellite
Microtubule Plus-end
Mitotic Spindle
Mitotic Spindle Pole
Spindle Pole
XY Body
Nucleus
Nucleolus
Cytoplasm
Centrosome
Centriole
Cytosol
Cleavage Furrow
Deuterosome
Molecular Function
Protein Binding
Microtubule Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Biological Process
Mitotic Sister Chromatid Segregation
Spindle Organization
Chromosome Segregation
Positive Regulation Of Intracellular Transport
Cell Division
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Protein Localization To Centrosome
Regulation Of Metaphase Plate Congression
Positive Regulation Of Spindle Assembly
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Protein Phosphorylation
Centriole Replication
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cytokinesis
Positive Regulation Of Centriole Replication
Trophoblast Giant Cell Differentiation
Ciliary Basal Body-plasma Membrane Docking
De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Drugs
Fostamatinib
Diseases
GWAS
Interacting Genes
55 interacting genes:
AMOTL2
ARNT2
ATN1
BARD1
C1orf109
CCDC33
CCHCR1
CDC20B
CDK1
CENPH
CHCHD3
DCX
EIF4E2
EIF4ENIF1
ENKD1
FBXO28
FMR1
GEM
GOLGA8EP
GOLGA8F
HAUS1
IGFN1
IQCE
KANSL1
KRT3
KRT75
LGALS14
LINGO1
MID1
MID2
NEBL
NLGN3
ODF1
ORC6
PIMREG
PKN1
PLK4
POLR2L
POM121
RBM41
SH2D4A
SMARCE1
SNAP47
SNAPIN
SPAG5-AS1
TSHZ3
TTC23
ZC2HC1C
ZFC3H1
ZFYVE26
ZGPAT
ZMAT2
ZNF385C
ZNF572
ZNF688
22 interacting genes:
ARR3
BTRC
C1orf109
CHD3
CYLD
DNAJB13
ELOA
GAS8
MTUS2
OSBPL3
PRDM16
SFN
SMAD4
SPAG5
TAX1BP3
TEC
TENT5B
TENT5C
TFIP11
TGFBR1
TRIM54
ZBTB39
Entrez ID
10615
10733
HPRD ID
10246
10387
Ensembl ID
ENSG00000076382
ENSG00000142731
Uniprot IDs
Q96R06
O00444
PDB IDs
2N19
3COK
4JXF
4N7V
4N7Z
4N9J
4YUR
4YYP
5LHY
5LHZ
6N45
6N46
6W38
6W3I
6W3J
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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