ZNRD2 and POLA2

Data Source:
BioGRID (affinity chromatography technology)

		ZNRD2	POLA2
Description		zinc ribbon domain containing 2	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component		Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Protein Binding	Molecular_function DNA Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Cell Division	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS			Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		26 interacting genes: ACTN2 C2CD6 CCDC33 CCNH CCT2 CCT3 CCT5 CCT7 FNDC11 FXR2 IL16 INCA1 MYO15B NME6 NOC4L PIAS2 RNF115 RNF4 SNAPC5 STAT3 SUMO1P1 TRAF3IP3 TRAPPC6A UBE2I VTA1 ZMYM5	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		10534	23649
HPRD ID		06921	10160
Ensembl ID		ENSG00000173465	ENSG00000014138
Uniprot IDs		G3V1B8 O60232	Q14181
PDB IDs		6HCZ	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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