FBXO2 and AHSG

Data Source:
HPRD (in vivo)

		FBXO2	AHSG
Description		F-box protein 2	alpha 2-HS glycoprotein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol SCF Ubiquitin Ligase Complex Organelle Membrane Dendritic Spine	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Amyloid-beta Binding Ubiquitin-protein Transferase Activity Protein Binding Carbohydrate Binding Ubiquitin Protein Ligase Activity	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Kinase Inhibitor Activity
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Proteolysis Glycoprotein Catabolic Process Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Post-translational Protein Modification	Skeletal System Development Platelet Degranulation Pinocytosis Acute-phase Response Negative Regulation Of Endopeptidase Activity Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Kinase Activity Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		16 interacting genes: AHSG BACE1 BRAP ECPAS IGH ITGB1 PAX4 PFDN6 SKP1 STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 VSTM1	8 interacting genes: CDC42 DCN FBXO2 FBXW7 GRB2 INSR RRAS2 VKORC1
Entrez ID		26232	197
HPRD ID		06171	00727
Ensembl ID		ENSG00000116661	ENSG00000145192
Uniprot IDs		Q9UK22	P02765
PDB IDs
Enriched GO Terms of Interacting Partners?
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