COG5 and MEFV

Data Source:
HPRD (two hybrid)

		COG5	MEFV
Description		component of oligomeric golgi complex 5	MEFV innate immuity regulator, pyrin
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Golgi Apparatus Cytosol Membrane Golgi Transport Complex Trans-Golgi Network Membrane	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle
	Molecular Function	Molecular_function Protein Binding	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Protein Transport Inter-Golgi Cisterna Vesicle-mediated Transport	Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) LDL cholesterol ( 30275531) Macular thickness ( 30535121) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Osteoarthritis ( 20112360) Pulse pressure ( 30224653 30578418) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Ankylosing spondylitis ( 30946743)
Interacting Genes		5 interacting genes: APC COG4 COG7 MEFV RAC1	12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1
Entrez ID		10466	4210
HPRD ID		08436	02012
Ensembl ID		ENSG00000164597	ENSG00000103313
Uniprot IDs		Q9UP83	D2DTW2 O15553
PDB IDs			2MPC 2WL1 4CG4
Enriched GO Terms of Interacting Partners?
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