ABCB11 and LY6D

Data Source:
BioGRID (two hybrid)

		ABCB11	LY6D
Description		ATP binding cassette subfamily B member 11	lymphocyte antigen 6 family member D
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Intercellular Canaliculus Intracellular Canaliculus Recycling Endosome Recycling Endosome Membrane Extracellular Exosome	Extracellular Region Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane
	Molecular Function	Transporter Activity Protein Binding ATP Binding P-type Sodium Transporter Activity ABC-type Xenobiotic Transporter Activity Bile Acid Transmembrane Transporter Activity Canalicular Bile Acid Transmembrane Transporter Activity ABC-type Bile Acid Transporter Activity ATPase Activity ATPase-coupled Transmembrane Transporter Activity	Protein Binding
	Biological Process	Fatty Acid Metabolic Process Bile Acid Biosynthetic Process Drug Transmembrane Transport Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Protein Ubiquitination Drug Metabolic Process Regulation Of Fatty Acid Beta-oxidation Sodium Ion Transmembrane Transport Cholesterol Homeostasis Xenobiotic Transport Drug Export Transmembrane Transport Lipid Homeostasis Phospholipid Homeostasis Positive Regulation Of Bile Acid Secretion Regulation Of Bile Acid Metabolic Process	Cell Adhesion Lymphocyte Differentiation Response To Stilbenoid
Pathways		Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective ABCB11 causes PFIC2 and BRIC2	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		ATP Glyburide
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Alanine transaminase levels ( 29403010) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010) Cholesterol, total ( 24097068) Egg allergy ( 25710614) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 18521185) Gamma glutamyl transferase levels ( 29403010) Glycated hemoglobin levels ( 24647736 20858683 31213470 29170429) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 21909109) Red cell distribution width ( 32888494) Systolic blood pressure in sickle cell anemia ( 24058526) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		4 interacting genes: DDIT4L HAX1 LY6D NR4A1	7 interacting genes: ABCB11 AQP6 ARFIP2 ELOVL4 PKIB TMEM31 TMEM86B
Entrez ID		8647	8581
HPRD ID		04436	09370
Ensembl ID		ENSG00000073734	ENSG00000167656
Uniprot IDs		O95342	Q14210
PDB IDs		6LR0
Enriched GO Terms of Interacting Partners?
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