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PKD2 and DIAPH1
Data Source:
HPRD
(in vivo)
PKD2
DIAPH1
Description
polycystin 2, transient receptor potential cation channel
diaphanous related formin 1
Image
No pdb structure
GO Annotations
Cellular Component
Polycystin Complex
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cilium
Basal Plasma Membrane
Membrane
Lamellipodium
Cytoplasmic Vesicle Membrane
Motile Cilium
Filamentous Actin
Cation Channel Complex
Ciliary Basal Body
Basal Cortex
Ciliary Membrane
Extracellular Exosome
Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Mitotic Spindle
Non-motile Cilium
Nucleus
Cytoplasm
Microtubule Organizing Center
Cytosol
Plasma Membrane
Secretory Granule Membrane
Ruffle Membrane
Mitotic Spindle
Ficolin-1-rich Granule Membrane
Molecular Function
Signaling Receptor Binding
Voltage-gated Ion Channel Activity
Voltage-gated Calcium Channel Activity
Voltage-gated Sodium Channel Activity
Voltage-gated Potassium Channel Activity
Cation Channel Activity
Calcium Channel Activity
Potassium Channel Activity
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Outward Rectifier Potassium Channel Activity
Voltage-gated Cation Channel Activity
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
HLH Domain Binding
Ion Channel Binding
Calcium-induced Calcium Release Activity
ATPase Binding
Phosphoprotein Binding
Muscle Alpha-actinin Binding
RNA Binding
Actin Binding
Signaling Receptor Binding
Protein Binding
Ion Channel Binding
Biological Process
Branching Involved In Ureteric Bud Morphogenesis
Liver Development
Embryonic Placenta Development
Heart Looping
Detection Of Nodal Flow
Calcium Ion Transport
Cell Cycle Arrest
Receptor Signaling Pathway Via JAK-STAT
Determination Of Left/right Symmetry
Heart Development
Negative Regulation Of Cell Population Proliferation
Wnt Signaling Pathway
Spinal Cord Development
Neural Tube Development
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Cellular Response To Reactive Oxygen Species
Metanephric Part Of Ureteric Bud Development
Sodium Ion Transmembrane Transport
Aorta Development
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Cilium Organization
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Detection Of Mechanical Stimulus
Release Of Sequestered Calcium Ion Into Cytosol
Protein Tetramerization
Protein Homotetramerization
Protein Heterotetramerization
Centrosome Duplication
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Placenta Blood Vessel Development
Renal Tubule Morphogenesis
Renal Artery Morphogenesis
Calcium Ion Transmembrane Transport
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Calcium Ion
Cellular Response To CAMP
Cellular Response To Hydrostatic Pressure
Cellular Response To Osmotic Stress
Cellular Response To Fluid Shear Stress
Potassium Ion Transmembrane Transport
Determination Of Liver Left/right Asymmetry
Metanephric Mesenchyme Development
Mesonephric Tubule Development
Mesonephric Duct Development
Metanephric Smooth Muscle Tissue Development
Metanephric Cortex Development
Metanephric Ascending Thin Limb Development
Metanephric Cortical Collecting Duct Development
Metanephric Distal Tubule Development
Metanephric S-shaped Body Morphogenesis
Regulation Of Calcium Ion Import
Inorganic Cation Transmembrane Transport
Cell-cell Signaling By Wnt
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cytoskeleton Organization
Sensory Perception Of Sound
Regulation Of Cell Shape
Actin Cytoskeleton Organization
Actin Filament Polymerization
Regulation Of Microtubule-based Process
Protein Localization To Microtubule
Neutrophil Degranulation
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Cytoskeleton Organization
Cellular Response To Histamine
Regulation Of Cell Motility
Pathways
VxPx cargo-targeting to cilium
VxPx cargo-targeting to cilium
RHO GTPases Activate Formins
ERBB2 Regulates Cell Motility
Neutrophil degranulation
Drugs
Diseases
Polycystic kidney disease
GWAS
Coffee consumption (cups per day) (
25288136
)
Dental caries (
23064961
)
Gout (
30899057
)
Hyperuricemia (
28776340
)
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Uric acid levels (
29558500
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Mean platelet volume (
32888494
27863252
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Interacting Genes
21 interacting genes:
ACTN2
CD2AP
CYSRT1
DIAPH1
HAX1
HSF2BP
KRT40
KRTAP10-3
KRTAP10-8
KRTAP6-2
LMNA
MAGEA8
MDFI
PACS1
PACS2
PKD1
PLSCR1
PTPRG
TNNI3
TPM1
TRPC1
17 interacting genes:
APBB1
BAIAP2
CDC42
CDC7
CENPA
GAS7
NEDD4
PAX6
PKD2
PRPF40A
PTPRF
RAC1
RHOA
RHOC
TCERG1
WBP4
XPO6
Entrez ID
5311
1729
HPRD ID
01437
03670
Ensembl ID
ENSG00000118762
ENSG00000131504
Uniprot IDs
Q13563
Q9UEU6
A0A2R8Y5N1
O60610
Q6URC4
PDB IDs
2KLD
2KLE
2KQ6
2Y4Q
3HRN
3HRO
5K47
5MKE
5MKF
5T4D
6A70
6D1W
6T9N
6T9O
6WB8
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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