MAEA and MYOC

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAEA	MYOC
Description		macrophage erythroblast attacher, E3 ubiquitin ligase	myocilin
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Spindle Actomyosin Contractile Ring Cytoskeleton Integral Component Of Plasma Membrane Nuclear Matrix GID Complex	Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Vesicle Node Of Ranvier Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Metal Ion Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding
	Biological Process	Cell Cycle Cell Adhesion Regulation Of Mitotic Cell Cycle Protein Ubiquitination Negative Regulation Of Myeloid Cell Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Negative Regulation Of Gluconeogenesis Cell Division	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Drugs		Tetrachlorodecaoxide
Diseases			Primary open angle glaucoma
GWAS		Obesity-related traits ( 23251661) Pulse pressure ( 30224653) Type 2 diabetes ( 30297969 26818947 23945395 32499647 22158537 30718926 28869590)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma ( 30104761) Intake of total sugars ( 31005972)
Interacting Genes		12 interacting genes: ARMC8 GID4 GID8 MKLN1 MYOC RANBP10 RMND5A UBE2D2 UBE2D3 UBE2H UBE2R2 YPEL5	41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		10296	4653
HPRD ID		08427	03387
Ensembl ID		ENSG00000090316	ENSG00000034971
Uniprot IDs		B3KRN7 B4DJP8 B4DQT1 B4DVN3 D6RIB6 Q7L5Y9	A0A0S2Z421 Q99972
PDB IDs			4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF
Enriched GO Terms of Interacting Partners?
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