SAP18 and POLE2

Data Source:
HPRD (in vitro, two hybrid)

		SAP18	POLE2
Description		Sin3A associated protein 18	DNA polymerase epsilon 2, accessory subunit
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck Exon-exon Junction Complex ASAP Complex	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Corepressor Activity RNA Binding Protein Binding Transcription Factor Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of MRNA Splicing, Via Spliceosome	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis
Pathways		HDACs deacetylate histones NoRC negatively regulates rRNA expression Potential therapeutics for SARS	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS
Interacting Genes		15 interacting genes: DEF6 ERBB3 HDAC1 IKZF1 INCA1 NOL12 NTAQ1 POLE2 RBM39 RNPS1 RPS3A SIN3A SUFU TADA3 TSC22D2	19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620
Entrez ID		10284	5427
HPRD ID		04256	16007
Ensembl ID		ENSG00000150459	ENSG00000100479
Uniprot IDs		O00422	P56282
PDB IDs		2HDE	2V6Z 5VBN
Enriched GO Terms of Interacting Partners?
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