U2AF2 and RBM11

Data Source:
BioGRID (two hybrid)

		U2AF2	RBM11
Description		U2 small nuclear RNA auxiliary factor 2	RNA binding motif protein 11
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GO Annotations	Cellular Component	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF Complex	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding	Single-stranded RNA Binding Protein Binding Poly(U) RNA Binding Protein Homodimerization Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Multicellular Organism Development RNA Splicing Cell Differentiation Cellular Response To Oxidative Stress
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Menopause (age at onset) ( 26414677)
Interacting Genes		75 interacting genes: APBB1 ATXN1 BEND7 CCAR1 CDC42 CHERP CHIC2 CPSF7 DACH1 DDX39B DDX6 DPPA2 DVL2 EPB41 FUBP1 GEMIN2 GLIS2 HLA-DMA HMBOX1 IL7R INO80B KHDC4 KHDRBS3 LURAP1 MAP1B MRPL15 NKAPD1 OTUB2 PHF5A PIN1 POLR2A PRPF3 PRPF40A PUF60 QKI RBFOX2 RBM11 RBM39 RBM4 RBMY1F RBMY1J SAP30BP SCAF11 SF1 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SRSF3 STAC3 SUGP1 SUMO2 TCERG1 TCF23 THAP1 TLE5 TOP1 U2AF1 U2AF1L5 WT1 ZNF107 ZNF526 ZNF57 ZNF71 ZNF835 ZRSR2 ZRSR2P1	24 interacting genes: APP DAZAP2 DDX6 DTX2 ENKD1 FAM214B GABPB1 GADD45GIP1 GLIS2 GPATCH2L MYO15B PCBP1 PIBF1 PPP1R32 QKI RHOXF2 SCNM1 SNRPA SNRPC U2AF2 ZFHX3 ZMYND10 ZNF414 ZNF774
Entrez ID		11338	54033
HPRD ID		01872	10185
Ensembl ID		ENSG00000063244	ENSG00000185272
Uniprot IDs		P26368	D3DSC2 P57052
PDB IDs		1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H 6TR0 6XLV 6XLW 6XLX	2YWK
Enriched GO Terms of Interacting Partners?
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