Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CDK8 and PRMT5
Data Source:
BioGRID
(affinity chromatography technology, pull down)
CDK8
PRMT5
Description
cyclin dependent kinase 8
protein arginine methyltransferase 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Mediator Complex
Protein-containing Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Methylosome
Histone Methyltransferase Complex
Molecular Function
Protein Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
P53 Binding
Transcription Corepressor Activity
Protein Binding
Methyltransferase Activity
Methyl-CpG Binding
Histone-arginine N-methyltransferase Activity
Protein-arginine N-methyltransferase Activity
Protein-arginine Omega-N Symmetric Methyltransferase Activity
Identical Protein Binding
Ribonucleoprotein Complex Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Protein Heterodimerization Activity
E-box Binding
Biological Process
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle
Spliceosomal SnRNP Assembly
DNA-templated Transcription, Termination
Regulation Of Transcription, DNA-templated
Regulation Of Mitotic Nuclear Division
Peptidyl-arginine Methylation
Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine
Circadian Regulation Of Gene Expression
Histone Arginine Methylation
Peptidyl-arginine N-methylation
Endothelial Cell Activation
Histone H4-R3 Methylation
Regulation Of DNA Methylation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of ERK1 And ERK2 Cascade
Golgi Ribbon Formation
Liver Regeneration
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Pathways
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Generic Transcription Pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
snRNP Assembly
RMTs methylate histone arginines
Regulation of TP53 Activity through Methylation
Drugs
Alvocidib
Diseases
GWAS
Immune response to measles-mumps-rubella vaccine (
24811271
)
Sporadic pituitary adenoma (
26029870
)
Cortical amyloid beta load (
29860282
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Interacting Genes
38 interacting genes:
AURKA
BCL6
BMPR1A
BUB1
CCNC
CCND1
CCNH
CDH1
CDKN2B
CTDP1
ERBB2
ERCC3
ESR1
ESR2
H3C14
KRAS
MAML1
MBP
MCC
MED12
MED21
MED25
MED26
MED8
MED9
MLH3
MYC
NRIP1
POLR2A
PRMT5
SMAD2
SMAD3
SMARCA4
SREBF1
SUZ12
TOP1
TP53
WDR77
91 interacting genes:
ARGLU1
C1orf109
CACNB2
CALU
CAPN1
CDC37
CDK19
CDK8
CDYL2
CLK1
CLK3
CLNS1A
CTDP1
DIO3
DNMT3A
DUSP14
EIF4A3
ELOA
EPHB6
EZH2
FAM76B
GAS8
GLI1
GRHL3
GTPBP2
H2AC20
H2AC4
H3-4
H3-5
H3C1
H4-16
H4C1
HOXC4
ILF3
ING5
JAK1
JAK2
JAK3
KANK2
LDHAL6B
LENG8
LNX1
LUC7L
MAGEB2
MBP
MCRS1
MEF2D
MYOD1
MYOG
NCL
NELFCD
NTAQ1
NUDCD2
OLA1
PDGFRA
PHYHIP
POLR2A
PRPF38A
RBM23
RSRP1
SF3A3
SIN3A
SLU7
SMARCA2
SMARCB1
SMARCC1
SMARCE1
SNRNP70
SNRPB
SNRPD1
SNRPD3
SPAG8
SREBF1
SSTR1
STUB1
SUPT5H
TRIB3
TRIM54
TYK2
UBE3A
WDR5
WDR77
YWHAG
YWHAQ
YWHAZ
ZDHHC17
ZMYND19
ZNF2
ZNF224
ZNF436
ZUP1
Entrez ID
1024
10419
HPRD ID
04422
04955
Ensembl ID
ENSG00000132964
ENSG00000100462
Uniprot IDs
P49336
B4DV00
O14744
PDB IDs
3RGF
4CRL
4F6S
4F6U
4F6W
4F70
4F7J
4F7L
4F7N
4F7S
4G6L
5BNJ
5CEI
5FGK
5HBE
5HBH
5HBJ
5HNB
5HVY
5I5Z
5ICP
5IDN
5IDP
5XQX
5XS2
6QTG
6QTJ
6R3S
6T41
4GQB
4X60
4X61
4X63
5C9Z
5EMJ
5EMK
5EML
5EMM
5FA5
6CKC
6K1S
6RLL
6RLQ
6UXX
6UXY
6V0N
6V0O
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?