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CDK8 and CCNC
Data Source:
HPRD
(in vivo, in vitro)
CDK8
CCNC
Description
cyclin dependent kinase 8
cyclin C
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Mediator Complex
Protein-containing Complex
Nucleus
Nucleoplasm
Mediator Complex
Molecular Function
Protein Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Identical Protein Binding
Biological Process
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Generic Transcription Pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Generic Transcription Pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Drugs
Alvocidib
Diseases
GWAS
Immune response to measles-mumps-rubella vaccine (
24811271
)
Sporadic pituitary adenoma (
26029870
)
Erectile dysfunction (
30297428
)
Refractive error (
32231278
)
Interacting Genes
38 interacting genes:
AURKA
BCL6
BMPR1A
BUB1
CCNC
CCND1
CCNH
CDH1
CDKN2B
CTDP1
ERBB2
ERCC3
ESR1
ESR2
H3C14
KRAS
MAML1
MBP
MCC
MED12
MED21
MED25
MED26
MED8
MED9
MLH3
MYC
NRIP1
POLR2A
PRMT5
SMAD2
SMAD3
SMARCA4
SREBF1
SUZ12
TOP1
TP53
WDR77
80 interacting genes:
ASH2L
BLOC1S2
BTBD2
CCHCR1
CCNH
CDK3
CDK8
CDKN2B
CFAP53
CKS1B
CRX
DYDC1
ERCC3
ESR2
FAM161A
FAM50B
FAM90A1
FOXP2
FOXR2
GADD45GIP1
GLYR1
GOLGA2
GPC4
HSPB1
ISY1
KRT13
KRT15
KRT16
KRT27
KRT31
KRT34
LCN2
LZTS2
MBD3
MBIP
MCM2
MED8
MEOX2
MGST3
MYO15B
NDUFB7
NDUFV2
NEFL
NMNAT1
NRBF2
PAX5
PBXIP1
PLEKHO2
PLIN3
PNMA5
POU6F2
PRPF18
PUF60
RB1
RBM41
REL
RFC5
RIBC1
RPA2
RUSC1
SERTAD3
SHC3
SPAG8
TADA3
TCEANC
TEPSIN
TEX12
TP63
TRAF3IP3
TRIM39
TRIM54
UBE2K
VHL
VTA1
ZFP90
ZNF18
ZNF426
ZNF620
ZNF688
ZNF792
Entrez ID
1024
892
HPRD ID
04422
00456
Ensembl ID
ENSG00000132964
ENSG00000112237
Uniprot IDs
P49336
P24863
Q7Z4L3
PDB IDs
3RGF
4CRL
4F6S
4F6U
4F6W
4F70
4F7J
4F7L
4F7N
4F7S
4G6L
5BNJ
5CEI
5FGK
5HBE
5HBH
5HBJ
5HNB
5HVY
5I5Z
5ICP
5IDN
5IDP
5XQX
5XS2
6QTG
6QTJ
6R3S
6T41
3RGF
4CRL
4F6S
4F6U
4F6W
4F70
4F7J
4F7L
4F7N
4F7S
4G6L
5BNJ
5CEI
5FGK
5HBE
5HBH
5HBJ
5HNB
5HVY
5I5Z
5ICP
5IDN
5IDP
5XQX
5XS2
6QTG
6QTJ
6R3S
6T41
Enriched GO Terms of Interacting Partners
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