TSPAN2 and MOV10

Data Source:
HPRD (in vivo)

		TSPAN2	MOV10
Description		tetraspanin 2	Mov10 RISC complex RNA helicase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Integral Component Of Plasma Membrane Integral Component Of Membrane Myelin Sheath	P-body Extracellular Space Nucleus Cytosol Cytoplasmic Stress Granule Cytoplasmic Ribonucleoprotein Granule P Granule
	Molecular Function	Protein Binding	RNA Binding Protein Binding ATP Binding 5'-3' RNA Helicase Activity
	Biological Process	Inflammatory Response Brain Development Astrocyte Development Microglia Development Myelination Oligodendrocyte Differentiation Axon Development	Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Transposition, RNA-mediated Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Viral Process Post-transcriptional Gene Silencing By RNA Gene Silencing By MiRNA MRNA Cleavage Involved In Gene Silencing By MiRNA Regulation Of Megakaryocyte Differentiation Defense Response To Virus Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Regulation Of Neuron Projection Arborization
Pathways			Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Dysmenorrheic pain ( 27454463) Ischemic stroke (large artery atherosclerosis) ( 26708676 29531354) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Migraine ( 27182965 23793025 27322543) Migraine without aura ( 23793025 27322543)	Blood pressure ( 21909110) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878 21909115 28739976 27618452 25249183 30487518) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Height ( 31562340) Hip circumference adjusted for BMI ( 25673412) Hypertension ( 21909115 25249183 30487518) Mean arterial pressure ( 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (diuretics) ( 31015401) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 21909115 28739976 27618452 25249183 30487518) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		35 interacting genes: ABHD16A ATP1B4 BSCL2 CD79A CLDN5 CLEC14A CREB3 CREB3L1 DCBLD2 FAM209A FKBP7 FOS GRB2 IFNGR2 KDELR3 LEPROTL1 LMNA MFF MGST3 PGRMC2 PIK3R3 RABGAP1L REEP4 RNF19B SCN3B SLC10A6 SLC30A8 SLC35C2 TMEM130 TMEM14B TMEM31 TMX2 TSPAN31 VSIR ZFYVE27	1 interacting genes: EIF2AK2
Entrez ID		10100	4343
HPRD ID		18233	14732
Ensembl ID		ENSG00000134198	ENSG00000155363
Uniprot IDs		B1AKP1 B2RD31 O60636	Q5JR04 Q9HCE1
PDB IDs
Enriched GO Terms of Interacting Partners?
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